cosmid(redirected from Cosmides)
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A recombinantly engineered plasmid, a circular DNA containing, in order: a plasmid origin of replication and a drug-resistance marker, the cos (cohesive end) site from bacteriophage λ, and a fragment of eukaryotic DNA to be cloned; cosmids are constructed to permit cloning of fragments of up to about 40,000 base pairs in length, with one or more unique restriction sites being necessary to facilitate cloning.
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An artificially constructed plasmid used for cloning large genes or other DNA sequences.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
cosmida class of CLONING VECTOR which comprises a bacterial PLASMID and the COS SITE of a BACTERIOPHAGE, typically bacteriophage lambda. A cosmid combines features of plasmids and of bacteriophages and can be used in CLONING. Large DNA fragments, up to 40 KILOBASE pairs in size, can be cloned in cosmids. The cosmid can be propagated as a plasmid in vivo and packaged into bacteriophages in vitro.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005