Corynebacterium diphtheriae


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Cor·y·ne·bac·te·ri·um diph·the·'ri·ae

a bacterial species that causes diphtheria and produces a powerful exotoxin causing degeneration of various tissues, notably myocardium, in humans and experimental animals, and catalyzing the ADP-ribosylation of elongation factor II; virulent strains of this organism are lysogenic; it is commonly found in membranes in the pharynx, larynx, trachea, and nose in cases of diphtheria; it is also found in apparently healthy pharynx and nose in carriers, and occasionally in the conjunctiva and in superficial wounds; it occasionally infects the nasal passages and wounds of horses; it is the type species of the genus Corynebacterium.

Corynebacterium diphtheriae

The causative agent of diphtheria, which produces a potent exotoxin Reservoir Humans Epidemiology Airborne, infected fomites, infected skin; more common in winter, with crowding, hot, dry air Incidence 5/105–US; attack rate in minorities is 5- to 20-fold that of whites Microbiology In culture, C diphtheriae are often arranged in aggregates fancifully likened to Chinese letters

Cor·y·ne·bac·te·ri·um diph·the·ri·ae

(kŏ-rī'nē-bak-tēr'ē-ŭm dif-thēr'ē-ē)
Typespecies of the genus Corynebacterium, thecause of diphtheria. It induces a severe membranous pharyngitis and produces an exotoxin that damages myocardium and other tissues; may also infect superficial wounds; an asymptomatic carrier state is common.
Synonym(s): Löffler bacillus.

Corynebacterium diphtheriae

The causative agent of diphtheria in humans.
See: diphtheria
See also: Corynebacterium
References in periodicals archive ?
Efficient discrimination within a Corynebacterium diphtheriae epidemic clonal group by a novel macroarray-based method.
Buescher ES Diphtheria (Corynebacterium diphtheriae).
When referring to thermal death points, it is apparent that Corynebacterium diphtheriae can be destructed at the lowest temperature (58[degrees]C), while Salmonella typhimurium, Brucella melitensis, Mycobacterium tuberculosis and group A streptococci can all be destroyed at 62[degrees]C, if exposed to this temperature for a certain time span (ranging from 20-21 seconds for Corynebacterium diphtheriae to up to 135-144 seconds for group A streptococci).
Pharyngeal or cutaneous diphtheria caused by toxigenic Corynebacterium diphtheriae and C.
An outbreak of nontoxigenic Corynebacterium diphtheriae infection: single bacterial clone causing invasive infection among Swiss drug users.
Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007-2008: a multicentre European study.
The return of Corynebacterium diphtheriae: the rise of non-toxigenic strains.
ulcerans infections can be clinically indistinguishable from toxigenic Corynebacterium diphtheriae infections.
(4) Other bacterial agents that occasionally cause pharyngitis and are reported when recovered include group B and C beta-hemolynic streptococci, Neisseria gonorrhoeae, Arcanobacterium haemolyticum, Corynebacterium diphtheriae, Chlamydia pneumoniae, and Mycoplasma spp.
Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR.
IHC using polyclonal antibodies for Corynebacterium diphtheriae showed rare epithelial staining in four of seven cases, although this test has unknown specificity.

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