Corynebacterium diphtheriae


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Cor·y·ne·bac·te·ri·um diph·the·'ri·ae

a bacterial species that causes diphtheria and produces a powerful exotoxin causing degeneration of various tissues, notably myocardium, in humans and experimental animals, and catalyzing the ADP-ribosylation of elongation factor II; virulent strains of this organism are lysogenic; it is commonly found in membranes in the pharynx, larynx, trachea, and nose in cases of diphtheria; it is also found in apparently healthy pharynx and nose in carriers, and occasionally in the conjunctiva and in superficial wounds; it occasionally infects the nasal passages and wounds of horses; it is the type species of the genus Corynebacterium.

Corynebacterium diphtheriae

The causative agent of diphtheria, which produces a potent exotoxin Reservoir Humans Epidemiology Airborne, infected fomites, infected skin; more common in winter, with crowding, hot, dry air Incidence 5/105–US; attack rate in minorities is 5- to 20-fold that of whites Microbiology In culture, C diphtheriae are often arranged in aggregates fancifully likened to Chinese letters

Cor·y·ne·bac·te·ri·um diph·the·ri·ae

(kŏ-rī'nē-bak-tēr'ē-ŭm dif-thēr'ē-ē)
Typespecies of the genus Corynebacterium, thecause of diphtheria. It induces a severe membranous pharyngitis and produces an exotoxin that damages myocardium and other tissues; may also infect superficial wounds; an asymptomatic carrier state is common.
Synonym(s): Löffler bacillus.

Corynebacterium diphtheriae

The causative agent of diphtheria in humans.
See: diphtheria
See also: Corynebacterium
References in periodicals archive ?
Clinical and molecular study of Corynebacterium diphtheriae systemic infections in France.
Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae.
Genotypic and phenotypic characteristics of Corynebacterium diphtheriae strains isolated from patients in Belarus during an epidemic period.
An increase in nontoxigenic Corynebacterium diphtheriae infections in Poland--molecular epidemiology and antimicrobial susceptibility of strains isolated from past outbreaks and those currently circulating in Poland.
Vaccination status of case-patients and clinical manifestations of toxigenic Corynebacterium diphtheriae infections and epidemiologically linked cases without laboratory confirmation, Latvia, Europe, 2000-2009 * Vaccination Classic diphtheria Mild diphtheria/ status (with membrane) severe pharyngitis Cutaneous Full 64 ([dagger]) 118 0 Partial 1 3 0 Unvaccinated 74 70 1 Not known 2 8 0 Total 141 199 1 Vaccination status Asymptomatic Not known Total Full 71 0 253 Partial 5 0 9 Unvaccinated 18 0 163 Not known 63 210 283 Total 157 210 708 * p<0.
The in-vitro susceptibilities of toxigenic strains of Corynebacterium diphtheriae isolated in northwestern Russia and surrounding areas to ten antibiotics.
Feline Corynebacterium diphtheriae isolates and reference strains used for comparison, West Virginia, 2008 * Strain Culture collection Source CD443 ATCC BAA-1774 Cat 1, right ear CD448 ND Cat 1, right ear CD449 ND Cat 1, left ear CD450 ND Cat 2, left ear C.
Polymerase chain reaction assay for diagnosis of potentially toxinogenic Corynebacterium diphtheriae strains: correlation with ADP-ribosylation activity assay.
Laboratory guidelines for the diagnosis of infections caused by Corynebacterium diphtheriae and C.
Humans are the only known reservoir for Corynebacterium diphtheriae.
Staphylococcus aureus, Streptococcus pyogenes, and toxigenic Corynebacterium diphtheriae var mitis were isolated from the specimens.
Antitoxin-in-membrane and antitoxin-in-well assays for detection of toxigenic Corynebacterium diphtheriae.

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