(koe-sin-troe-pin) ,


(trade name)


Therapeutic: diagnostic agents
Pharmacologic: hormones
Pregnancy Category: C


Adrenocortical insufficiency.


A synthetic form of corticotropin (ACTH); stimulates the adrenal gland to primarily produce corticosteroids (hydrocortisone) and a small amount of mineralocorticoids (aldosterone). Action requires intact adrenal responsiveness.

Therapeutic effects

Production of adrenal steroids after administration.


Absorption: Rapidly absorbed.
Distribution: Removed from plasma to many tissues.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile (effects on plasma cortisol levels)

IM, IV5 min45–60 minunknown


Contraindicated in: Hypersensitivity.
Use Cautiously in: Obstetric / Lactation: Pregnancy or lactation (safety not established).

Adverse Reactions/Side Effects


  • hypersensitivity reactions including anaphylaxis (life-threatening)


Drug-Drug interaction

Corticosteroids, estrogens, and spironolactone alter the results of testing.


Intramuscular Intravenous (Adults and Children >2 yr) 0.25 mg.
Intramuscular Intravenous (Children <2 yr) 0.125 mg.

Availability (generic available)

Powder for injection: 0.25 mg/vial

Nursing implications

Nursing assessment

  • In patients with a history of allergic reactions, monitor for hypersensitivity response (wheezing, rash or hives, and erythema) Cosyntropin is less likely than ACTH to cause such a response.
  • Lab Test Considerations: Plasma cortisol concentrations will be measured before and 30 or 60 min after administration of cosyntropin. Therapeutic response is a rise in the plasma cortisol of at least 7 mcg/dL above baseline or a final concentration of at least 18 mcg/dL. In patients with septic shock, a therapeutic response is defined as a rise in the plasma cortisol of at least 9 mcg/dL. Administration of corticosteroids, estrogens, or spironolactone on day of test will interfere with test results by causing elevated baseline plasma cortisol concentrations.

Potential Nursing Diagnoses

Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Do not confuse Cortrosyn with colchicine.
  • May be administered IM, direct IV, and by IV infusion.
    • Reconstitute 250-mcg vial with 1 mL of 0.9% NaCl for IM injection.
    • Discard unused reconstituted cosyntropin.
  • Intravenous Administration
  • Reconstitute 250-mcg vial with 2–5 mL of 0.9% NaCl for direct IV injection.
  • Rate: Administer over 2 min
  • Intermittent Infusion: Diluent: May be further diluted in 50 mL of D5W or 0.9% NaCl. Stable for 12 hr at room temperature or 21 days if refrigerated.
  • Rate: Infuse at a rate of 40 mcg/hr over 6 hr.

Patient/Family Teaching

  • Explain purpose of cosyntropin and need for lab tests.

Evaluation/Desired Outcomes

  • Differentiation of primary from secondary adrenocortical insufficiency.
Drug Guide, © 2015 Farlex and Partners


A trademark for the drug cosyntropin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
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References in periodicals archive ?
The Amphastar Pharmaceuticals' logo and other trademarks or service marks of Amphastar Pharmaceuticals, Inc., including, but not limited to Primatene, Amphadase and Cortrosyn, are the property of Amphastar Pharmaceuticals, Inc.
Administration of cosyntropin (1-24 ACTH; Cortrosyn) to directly stimulate adrenal cortisol release is the most commonly used diagnostic test to evaluate adrenal function.
The short adrenocorticotropic hormone (ACTH) stimulation test (Cortrosyn 250[micro]g) is the most commonly used dynamic evaluation to confirm the diagnosis of AI [2].
Inclusion criteria for the study were (1) age 18 or more and (2) a documented ACTH stimulation test (Cortrosyn stimulation test).
Although the level of serum adrenocorticotropic hormone (ACTH) was elevated (131.3 pg/mL; normal range, 7.2-63.3 pg/mL) at the time of the diagnosis of cryptococcosis (Table 1), cortisol release in response to ACTH (Cortrosyn), which was evaluated 1 day after prednisolone cessation, was increased (Table 2).
Synthetic ACTH (cosyntropin, Cortrosyn) is preferred for consistency; ACTH gels are not recommended for this test, because the results may not be accurate.
Increase in sales of other finished pharmaceutical products, such as Cortrosyn, atropine, sodium bicarbonate, and dextrose which were in high demand due to market shortages, as well as sales of Isoproterenol which we launched in the third quarter of 2018
Amphastar's logo and other trademarks or service marks of Amphastar, including, but not limited to Primatene, Amphadase and Cortrosyn, are the property of Amphastar.