(redirected from Corticotropes)


a type of acidophil found in the anterior lobe of the pituitary gland that secretes corticotropin; it is synthesized as a large prohormone containing both corticotropin and β-lipotropin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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Binding of CRH to its receptor on pituitary corticotropes induces the release of adrenocorticotropic hormone (ACTH) into the systemic circulation.
Endogenous corticosteroids may have their primary actions at brain and hypothalamic sites and synthetic glucocorticoids that do not bind to transcortin may act primarily on corticotropes and regions of brain outside the blood-brain barrier [27-29].
Pituitary adenomas can be derived from a single mutant cell of five differentiated cell types within pituitary gland: somatotropes, lactotropes, corticotropes, thyrotropes, and gonadotropes, which, respectively, secrete growth hormone (GH), prolactin (PRL), adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), and gonadotropins (follicle-stimulating hormone (FSH) and luteinizing hormone (LH)).
SP22 was not observed in large gonadotropes or corticotropes. Additional slides were fluorescently co-labeled with SP22 and one of the AP hormones and examined by confocal microscopy.
The rare cell types, including corticotropes and thyrotropes (Figure 3), showed similar changes at the corresponding time points.