SERPINA6

(redirected from Corticosteroid Binding Globulin)
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SERPINA6

A gene on chromosome 14q32.1 that encodes an alpha-globulin with corticosteroid-binding properties, which is the major transport protein for glucocorticoids and progestins in most vertebrates. SERPINA6 localises to a chromosomal region containing several closely related serine protease inhibitors, and may have evolved by duplication events.
References in periodicals archive ?
The objective of the present study was to investigate the presence of CBG (corticosteroid binding globulin), estrogens alpha and progesterone receptors in the uterus, oviduct and ovary of sheep during oestrous cycle (n = 3), pregnancy (n = 3), and in anoestrous (n = 3).
During normal pregnancy there is increased production of corticosteroid binding globulins by the liver and increased placental production of cortisol releasing hormone (CRH) and adrenocorticotropic hormone (ACTH); this causes elevated levels of total and free cortisol which may result in increased salivary and urinary free cortisol levels (Table-1).