The company has revealed results from a new sub-analysis of the Phase III PEGASUS-TIMI 54 trial, indicating a decrease of risk by 19 percent in MACE III PEGASUS-TIMI 54 trial, demonstrating a risk reduction of 19 percent in MACE (the composite of CV death, myocardial infarction, or stroke) from treatment with Brilinta 60mg, in people who had survived a heart attack and had stenosis in two or more coronary blood vessels
, a condition known as multi-vessel disease (MVD).
The study also reveals that the exact cause of the condition is not known yet but experts claim that "surging stress hormones (for example, adrenaline) essentially 'stun' the heart, triggering changes in heart muscle cells or coronary blood vessels
(or both) that prevent the left ventricle from contracting effectively.
5,6 The exact cause is not known but some experts propose a sudden surge of catecholamines which stun the heart and trigger changes in myocardium or coronary blood vessels
, or both, thus preventing the left ventricle from contracting effectively.
Each volunteer had his or her heart rate and blood pressure measured at rest, as well as coronary vascular conductance, a Doppler ultrasound measure of blood flow through the coronary blood vessels
of the heart.
Transcatheter aortic heart valve surgery uses a small, collapsible heart valve, packaged within a balloon-expandable stent, similar to what is used routinely to open and reinforce coronary blood vessels
Not only can we see if there are areas of narrowing in the coronary blood vessels
, but we can also see areas of plaque build-up that may not yet be causing narrowing, but might nonetheless benefit from preventative treatments.
there is already evidence of cholesterol plaque formation in their coronary blood vessels
due to their high saturated fat diets and lack of regular exercise.
Success stories range from hydrophilic coatings that increase lubricity of catheters passed through peripheral blood vessels to access the heart, to drug-eluting coatings on stents that keep coronary blood vessels
By carrying this gene vector into the coronary circulation, it should help the cells that form coronary blood vessels
Angina is treated with drugs that widen the coronary blood vessels
and reduce the heart's consumption of oxygen during stress and exercise.
His team found that even in the presence of oxygen levels that would not normally trigger vessel dilation, drugs that lower intracellular ATP concentrations still open coronary blood vessels