CORIN

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CORIN

A gene on chromosome 4p13-p12 that encodes a serine-type endopeptidase which converts non-functional propeptide NPPA into active atrial natriuretic peptide hormone, resulting in natriuresis, diuresis and vasodilation. CORIN may also process pro-NPPB, the B-type natriuretic peptide.

Molecular pathology
Defects in CORIN cause pre-eclampsia/eclampsia type 5.
References in periodicals archive ?
Dutton suggests that the Gogmagog story was so well known at the time that Shakespeare's audiences would have recognized the analogy between the fiend on the cliff in Lear and the Gogmagog wrestled by Corineus.
He then encounters Gawain, who recounts the exploits of Corineus and the Trojan origins of Britain.
The story begins with the settlement of Britain by Brutus the Trojan, great-grandson of Aeneas, and by the Trojan Corineus, the eponymous founder of Cornwall, who exterminate giants inhabiting Britain.
/ Said they would not tolerate, just for alien treasure, / That there should be this quarrel between Corineus and Locrin: / `But we will give counsel, this advice we confer: / That we give to Locrin Gwendoline to be our Queen, / And keep all the oaths we made to Corineus and Locrin, / And preserve the people's love with most profound intent, / And send Astrild away, out of this country.'/ Locrin had to approve of this, as it was his people's advice: / So he took Gwendoline and had her as his wife, / And he told them this (though it was not true) / That now Astrild would be sent right out of the country.