Research has shown that soluble klotho can still act as a coreceptor
for FGF-23 signaling , although it is believed to not be as active as the membrane form.
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor
IL-33 signals via a complex composed of ST2, the primary binding receptor, and a coreceptor
, IL-1R AcP, leading to MyD88- and IRAK-dependent MAP kinase and NF-[kappa]B activation.
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Homozygous defect in HIV-1 coreceptor
accounts for resistance of some multiply-exposed individuals to HIV-1 infection.
As a most interesting result, they found that the presence of the coreceptor
seems to influence the dynamics within the protein complex, in particular the relative movements of the two [alpha]-helices, G[alpha]1 and G[alpha]2.
Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor
use by HIV-1," Proceedings of the National Academy of Sciences of the United States of America, vol.
Once Wnt ligand binds to a Frizzled family receptor and a coreceptor
of the LRP-5/6/arrow family, the disheveled signal transduction molecules are activated, resulting in the phosphorylation of GSK3[sz] at position Ser9 and subsequent inactivation of GSK3[sz].
A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor
Two distinct CCR5 domains can mediate coreceptor
usage by human immunodeficiency virus type 1.
A) We hypothesize that high levels of immune activation predispose for a coreceptor
TLR antagonist or TLR-coreceptor
antagonist that prevents the binding of pathogenic ligands to the TLR or coreceptors
and generates anti-allergic activity.