coreceptor

co·re·cep·tor

(kō'rē-sep'tōr),
A cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions.

co·re·cep·tor

(kō'rĕ-sep'tŏr)
A cell surface protein that increases the sensitivity of the antigen receptor to antigen by binding to other ligands.

coreceptor

(ko?re-sep'tor) [ com- + receptor]
A structure on a cell membrane that enhances the action of the cell receptor.

CCR5 coreceptor

A cell surface receptor found on macrophages that facilitates entry of HIV-1 into these cells. Chemokines released by T cells attempt to compete with HIV by blocking the receptor to prevent infection.

CXCR4 coreceptor

A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells.
Synonym: fusin
References in periodicals archive ?
Research has shown that soluble klotho can still act as a coreceptor for FGF-23 signaling [25], although it is believed to not be as active as the membrane form.
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.
IL-33 signals via a complex composed of ST2, the primary binding receptor, and a coreceptor, IL-1R AcP, leading to MyD88- and IRAK-dependent MAP kinase and NF-[kappa]B activation.
Global Markets Direct's, 'C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5) - Pipeline Review, H1 2016', provides in depth analysis on C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5) targeted pipeline therapeutics.
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.
As a most interesting result, they found that the presence of the coreceptor seems to influence the dynamics within the protein complex, in particular the relative movements of the two [alpha]-helices, G[alpha]1 and G[alpha]2.
Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1," Proceedings of the National Academy of Sciences of the United States of America, vol.
Once Wnt ligand binds to a Frizzled family receptor and a coreceptor of the LRP-5/6/arrow family, the disheveled signal transduction molecules are activated, resulting in the phosphorylation of GSK3[sz] at position Ser9 and subsequent inactivation of GSK3[sz].
A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
A) We hypothesize that high levels of immune activation predispose for a coreceptor switch.
TLR antagonist or TLR-coreceptor antagonist that prevents the binding of pathogenic ligands to the TLR or coreceptors and generates anti-allergic activity.