hepatitis B serology

(redirected from Core antibody)

hepatitis B serology

Hepatitis B serological markers Lab medicine A generic term referring to hepatitis B antigens and antibodies to these antigens
Hepatitis B serology
Core antigen The HBc particle that contains double-stranded DNA and DNA polymerase, and is associated with the HBe antigen; HBc is not directly detected by currently-used assays; its presence indicates persistently replicating hepatitis B virus
Core antibody A long-term serologic marker for HBV, with 2 antibodies
IgM HBcAb A marker of acute infection, which rises early–within 2-4 weeks of HBV infection and slowly disappears; ↓ levels of IgM HBcAb indicate resolving infection; IgM HBcAb is the best serologic marker for acute HBV infection
IgG HBcAb A 'convalescent' antibody that indicates prior HBV infection; it rises 4-6 months after infection and persists for life, especially in those with active liver disease; partially protective anti-HBc antibody levels can be induced by recombinant vaccination, but are short-lived
e antigen An antigen that rises and falls parallel to HBsAg, and derives from the proteolytic cleavage of the nucleocapsid; its presence implies a carrier state
e antibody Anti-HBe An antibody that rises as HBe falls, appearing in convalescent Pts, persisting for up to several years after resolution of hepatitis
Surface antigen HBsAg The first marker to appear after HBV infection, preceding clinical disease by weeks, peaking with the onset of symptoms and disappearing six months post-infection; as long as HBsAg is positive, the Pt is considered infectious and must follow prescribed sanitary procedures to avoid infecting others; if the hepatitis does not resolve, HBsAg persists and can be detected for many years or life.
Antibody to surface antigen HBsAb, anti-HBs, antibody to surface antigen HBsAb begins to rise as the HBsAg falls; it is detectable 8-10 weeks post infection, is regarded as being protective against re-infection, and persists for life; HBsAb is formed after using the HBV vaccine, and is not present in the chronic phase of the disease.  
References in periodicals archive ?
Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.
From 2010 to 2017, hepatitis B surface antigen (HBsAg) positivity remained constant (0.1%), total hepatitis B core antibody (anti-HBc) positivity (indicating previous or ongoing HBV infection) decreased slightly (from 5.0% to 4.7%), anti-HCV positivity increased (4.2% to 7.3%), and anti-HIV positivity increased slightly (0.0% to 0.1%).
The HBsAg and Hepatitis B core antibody (HBcAb) status of an organ donor or recipient determine the risk of infection and transmission of HBV following transplantation.
Hepatitis B can be initially diagnosed by hepatitis B core antibody - one of the earliest proteins of immune system detected after viral infection starts.
Hepatitis B core antibody testing in countries endemic for HBV is also not suitable because of the high prevalence of individuals who harbor these antibodies.
Newark USA), hepatitis B core antibody (anti- HBc; bioELISA anti HBc, Biokit, Barcelona, Spain), Anti-hepatitis C Virus (anti-HCV; Hepanostika HCV ultra, Beijing United Biomedical Co.
Contract awarded for Reagent For Detection Delanticuerpo Surface Against The Antigen Hepatitis B Virus / Hepatitis B Core Antibody Detection
The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study.
Results of hepatitis B core antibody (anti-HBc) tests were available for 61 patients (10 positive, 16.3%); results of hepatitis B surface antibody (anti-HBs) tests were available for 64 patients (20 positive; 31.3%).
Resolved HBV infection is diagnosed on the seropositivity for Hepatitis B core antibody along with Hepatitis B surface antibodies.
N/A = not applicable; ND = not done; MSM = men who have sex with men; HBV = hepatitis B virus; HBsAg = hepatitis B surface antigen; HBeAg = HBV e antigen; anti-HBc = hepatitis B core antibody; anti-HBs = hepatitis B surface antibody.