coenzyme Q10

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coenzyme Q10

A factor present in mitochondria which extracts energy from foods. It has acquired a reputation among fringe nutritionists as being effective in detoxifying patients with an overdose of environmental pollutants; it is also claimed to be beneficial in treating hypertension, obesity, periodontal disease, preventing cancer, increasing longevity and revitalising the immune system.

coenzyme

(ko-en'zim?) [ co- + enzyme]
An enzyme activator; a diffusible, heat-stable substance of low molecular weight that, when combined with an inactive protein called apoenzyme, forms an active compound or a complete enzyme called a holoenzyme (e.g., adenylic acid, riboflavin, and coenzymes I and II).

coenzyme A

A derivative of pantothenic acid, important as a carrier molecule for acetyl groups in many reactions including the Krebs cycle (tricarboxylic acid cycle) and the oxidation of fatty acids.

coenzyme Q

A dietary supplement promoted by alternative medicine practitioners as an antioxidant and as a treatment for gingivitis and heart diseases.

coenzyme Q10

Ubiquinone.

coenzyme Q10

also known as ubiquinone, a non-essential lipid-soluble nutrient found predominantly in animal foods and at low levels in plant foods. In the body it is located primarily in the mitochondria, especially in skeletal and cardiac muscle. As a component of the electron transport chain, it is important for ATP formation. It is also believed to have an antioxidant function, protecting DNA and cell membranes from oxidative damage. For athletes, coenzyme Q10 supplements are claimed to enhance energy production through the electron transport chain, and to reduce the oxidative damage of exercise. Research does not support the claim, reporting either no effect or in some cases an ergolytic rather than ergogenic effect. See also ergogenic aids; appendix 4.4 .

coenzyme Q,

n an enzyme along the electron transport chain. Scientific name: 2,3 dimethoxy-5 methyl-6-decaprenyl benzoquinone; uses: heart disease—including ischemic heart disease, dysrhythmias, congestive heart failure, hypertension, angina pectoris, mitral valve prolapse—diabetes, infertility, Bell's palsy, periodontal disease; precautions: pregnancy, lactation, children; can cause nausea, diarrhea, epigastric pain. Also called
Co-Q10, mitoquinone, ubidecarenone, and
ubiquinone.
References in periodicals archive ?
and CoQ10 tablets manufactured by Elder Pharmaceuticals Ltd.
17) MitoQ researchers finally achieved success in enhancing the delivery of CoQ10 into the mitochondria when they attached the ubiquinol form of CoQ10 to the lipophilic triphenylphosphonium cation, which allowed CoQ10 to enter into the mitochondria driven by the large mitochondrial membrane potential.
Asemi and colleagues found that 100 mg of CoQ10 per day in subjects with metabolic syndrome improved markers of insulin metabolism.
Effectiveness of CoQ10 oral supplements as an adjunct to scaling and root planing in improving periodontal health.
It is reported that findings regarding the CoQ10 deficiency are available in cases such as cardiac failure, angina pectros, cardiomyopathy, hypertension, mitral valve prolapsus and atherosclerosis (Singh et al.
CoQ10 (Health Burst, USA) was provided by Pourateb Pharmaceutical Co.
Enriched mitochondrial fractions were then forwarded for immediate diagnostic biochemical analysis (see below), and when stated, for CoQ10 quantification.
CoQ10 also halved the risk of dying from all causes, which occurred in 18 (9 percent) patients in the CoQ10 group compared to 36 (17 percent) patients in the placebo group (hazard ratio=2.
Creatine, Glutamine and CoQ10 not only increase the rate at which energy is stored, but also help to produce energy by firing up the powerhouse in muscle cells called, mitochondria.
Different studies have shown an association (although not a significant one) between higher levels of circulating CoQ10 and reduced PCa risk.
CoQ10 also facilitates and regulates the production of reactive oxygen species (ROS) during cellular respiration, thereby maintaining the optimum ratio of pro-oxidant and antioxidant activity within the cell (Linnane & Eastwood, 2004).
Clinical trials, such as the CoQ10 trial described here, provide the only mechanism for obtaining FDA approval for new treatments.