Coombs test


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Coombs test

(kūmz),
a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.
Synonym(s): antiglobulin test

Coombs test

(kūmz test)
A procedure for measuring antibodies, the so-called anti-human globulin test, using either the direct or indirect Coombs tests.

Coombs test

(Koomz)
[R. R. A. Coombs, Brit. immunologist, b. 1921]
A laboratory test for the presence of antibodies, usually blood type antibodies, in serum. The patient's serum is incubated with red blood cells (RBCs) with known antigenic markers; if antibodies to the antigen are present in the serum, they bind with the RBCs. When antihuman globulin is added, RBC clumping (agglutination) occurs. The test is used for crossmatching blood before transfusions to ensure that no antigen-antibody reactions will occur and to test for the presence of specific antibodies to RBCs.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
References in periodicals archive ?
Coombs test results were reported to have become negative in more than 4 cases with improvement of anemia in all patients (3), (12) with prolonged administration of MDMP treatment, as in the presented patient.
It was learned that the baby had normal female karyotype in the prenatal follow-up, inversion (9) (p11;q13) which did not affect the phenotype was found, direct, indirect Coombs tests and TORCH and parvovirus serologic tests were negative and erythrocyte transfusion was performed by chordocentesis one week before the birth.
31 -- Direct coombs test -- -- Negative -- Anti-HAV -- -- Negative -- Anti-HBC -- -- Negative -- HBsAg -- -- Negative -- Anti-HBs -- -- Negative -- Anti-HCV -- -- Negative -- Anti-AMA <1/20 -- Negative -- ALP = alkaline phosphatase; ALT = alanine aminotransferase; anti-AMA = antimitochondrial antibodies, anti-HAV = hepatitis A virus antibody; anti-HBs = hepatitis B surface antibody; anti-HBV = hepatitis B virus antibody; anti-HCV = hepatitis C virus antibody; AST = aspartate aminotransferase; GGT = A-glutamyltransferase; HBsAg = hepatitis B surface antigen
A positive direct Coombs test indicates the presence of antibodies or complement on the surface of erythrocytes and is the hallmark of autoimmune hemolysis.
This would pertain providing the intended recipient has a negative atypical antibody screen and direct Coombs test and a negative transfusion reaction history.
pneumoniae infection, including Guillain-Barre-like illness and other central nervous system manifestations, hemolytic anemia, positive Coombs test, thrombocytopenia, and arthritis (4).
First of all, Coombs test was negative two out of 13 patients with hemolytic anemia (patients 3 and 10).
Contract awarded for monoclonal igg coombs test board reference: board monoclonal igg coombs, methodology gel
The combination of anemia, reticulocytopenia, hydrops fetalis, and a positive indirect Coombs test suggested Kell isoimmunization.
Diagnoses were based on low-level hemoglobin, fragmented red cells, microspherocytes, polychromasia, macrocytosis, nucleated red cells on peripheral blood smear, elevated reticulocytes, and positive direct Coombs test (IgG+C3).
In the present pregnancy, indirect Coombs test was found positive (anti-D antibody titer 1:256) and the fetus received intrauterine 120 ml and 240 ml 0 Rh-negative red cell concentrate transfusions in the 29th and 31st weeks, respectively.