Coombs test


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Coombs test

(kūmz),
a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.
Synonym(s): antiglobulin test

Coombs test

(kūmz test)
A procedure for measuring antibodies, the so-called anti-human globulin test, using either the direct or indirect Coombs tests.

Coombs test

(Koomz)
[R. R. A. Coombs, Brit. immunologist, b. 1921]
A laboratory test for the presence of antibodies, usually blood type antibodies, in serum. The patient's serum is incubated with red blood cells (RBCs) with known antigenic markers; if antibodies to the antigen are present in the serum, they bind with the RBCs. When antihuman globulin is added, RBC clumping (agglutination) occurs. The test is used for crossmatching blood before transfusions to ensure that no antigen-antibody reactions will occur and to test for the presence of specific antibodies to RBCs.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
References in periodicals archive ?
These antibodies can cross the placenta and may lead to a positive indirect Coombs test in the mother.
9 15-50 Double-stranded DNA Negative Negative (dsDNA) antibody Direct coombs test (IgG) ++++Positive Negative Ig: Immunoglobulin; RPR: Rapid plasma regain; DNA: Deoxyribonucleic acid.
After taking history and performing physical examination, blood tests were run for complete blood count, peripheral smear, reticulocyte count, coombs test, serum bilirubin, mother and baby's blood group.
Important distinguishing features that may assist in diagnosing TTP in this context include the presence of schistocytes on peripheral smear, a negative Coombs test, normal complement levels, and a low level of ADAMTS13 activity.
A positive Coombs test requires cautious interpretation when there are no other features of autoimmune hemolytic anemia.
1,2 The revised diagnostic criteria include thrombocytopenia and microangiopathic haemolytic anaemia along with raised LDH and negative coombs test.
Coombs test results were reported to have become negative in more than 4 cases with improvement of anemia in all patients (3), (12) with prolonged administration of MDMP treatment, as in the presented patient.
2] concluded that 'post-phototherapy neonatal bilirubin rebound to clinically significant levels may occur, especially in cases of prematurity, direct Coombs test positivity, and those treated [greater than or equal to] 72 hours'.
4 mg/dL, direct Coombs test was positive (warm, polyspecific IgG), and so was the indirect Coombs test.
The patient was negative for hepatitis A, B, and C virus antibodies and antimitochondrial antibodies and had a negative direct Coombs test result.
Diagnosis of CAHA is based on a positive direct Coombs test in the presence of cold agglutinins.
Moreover, results of a direct Coombs test were negative, although a routine peripheral blood smear revealed the presence of "bite cells.