Coombs test

(redirected from Coombs reagent)

Coombs test

(kūmz),
a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.
Synonym(s): antiglobulin test

Coombs test

(kūmz test)
A procedure for measuring antibodies, the so-called anti-human globulin test, using either the direct or indirect Coombs tests.

Coombs test

(Koomz)
[R. R. A. Coombs, Brit. immunologist, b. 1921]
A laboratory test for the presence of antibodies, usually blood type antibodies, in serum. The patient's serum is incubated with red blood cells (RBCs) with known antigenic markers; if antibodies to the antigen are present in the serum, they bind with the RBCs. When antihuman globulin is added, RBC clumping (agglutination) occurs. The test is used for crossmatching blood before transfusions to ensure that no antigen-antibody reactions will occur and to test for the presence of specific antibodies to RBCs.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
References in periodicals archive ?
Since 1945, the Coombs reagent source has been immunized rabbit blood serum.
Gamma completed field testing on the monoclonal Coombs reagents and filed with the FDA in November 1990.