controlled substance

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substance

 [sub´stans]
1. physical material that has form and weight; called also matter.
2. the material constituting an organ or body.
substance Abuse and Mental Health Services Administration (SAMHSA) an agency of the United States Department of Health and Human Services, created in 1992 to oversee the quality and availability of programs for prevention, treatment, and rehabilitation of substance abuse and related mental health problems.
black substance substantia nigra.
controlled substance a psychoactive substance that is regulated under the controlled substances act. See table at drug dependence.
depressor substance
gray substance gray matter.
ground substance the gel-like material in which connective tissue cells and fibers are embedded.
substance-induced disorders a subgroup of the substance-related disorders comprising a variety of behavioral or psychological anomalies resulting from ingestion of or exposure to a drug of abuse, medication, or toxin. Included are substance intoxication, substance withdrawal, and other mental disorders such as dementia, mood disorder, and psychotic disorder when they are specifically caused by a substance. See also substance use disorders.
medullary substance
1. the white matter of the central nervous system, consisting of axons and their myelin sheaths.
2. the soft, marrow-like substance of the interior of such structures as bone, kidney, and adrenal gland.
müllerian inhibiting substance a glycoprotein produced by the Sertoli cells of the fetal testis that acts ipsilaterally in the male to suppress the müllerian ducts, consequently preventing development of the uterus and fallopian tubes, thus helping to control formation of the male phenotype.
substance P a peptide composed of 11 amino acids, present in nerve cells scattered throughout the body and in special endocrine cells in the gut; it increases the contractions of gastrointestinal smooth muscle and causes vasodilatation; it is one of the most potent vasoactive substances known, and it seems to be a sensory neurotransmitter involving pain, touch, and temperature.
perforated substance
1. anterior perforated substance, an area anterolateral to each optic tract, pierced by branches of the anterior and middle cerebral arteries.
2. posterior perforated substance, an area between the cerebral peduncles, pierced by branches of the posterior cerebral arteries.
pressor substance vasopressor (def. 2).
psychoactive substance (psychotropic substance) any chemical compound that affects the mind or mental processes, particularly a drug used therapeutically in psychiatry, or any of various other types of mind-altering substances such as drugs of abuse and some toxins. See also table at drug dependence. Called also psychoactive agent or drug and psychotropic agent or drug.



There are several different classes of psychoactive substances: antidepressants are used for the relief of symptoms of major depression. lithium is the most common agent used to treat manic episodes of bipolar disorder. antipsychotic agents (or major tranquilizers) are used for management of the manifestations of psychotic disorders such as schizophrenia. antianxiety agents (called also minor tranquilizers), such as diazepam (Valium), are used for relief of anxiety disorders. While none of these drugs can effect a cure, they can reduce the severity of symptoms and permit the patient to resume more normal activity.

Also included in the category of psychotropic drugs are many other substances that affect the mind but are not used to treat mental disorders, including stimulants such as caffeine, amphetamines, and cocaine; opiates; and hallucinogens.
substance-related disorders any of the mental disorders associated with excessive use of or exposure to psychoactive substances, including drugs of abuse, medications, and toxins. The group is divided into substance use disorders and substance-induced disorders, each of which is specified on the basis of etiology, such as alcohol use disorders. See also drug abuse and drug dependence.
slow-reacting substance of anaphylaxis SRS-A, an inflammatory agent released by mast cells in the anaphylactic reaction. It induces slow, prolonged contraction of certain smooth muscles and is an important mediator of allergic bronchial asthma.
threshold s's those substances in the blood, such as glucose, that are excreted when they reach their renal threshold.
transmitter substance neurotransmitter.
substance use disorders a subgroup of the substance-related disorders, in which psychoactive substance use or abuse repeatedly results in significantly adverse consequences. The group comprises substance abuse (see drug abuse) and substance dependence (see drug dependence); specific disorders or groups of disorders are named on the basis of etiology, e.g., alcohol use disorders, alcohol abuse, and alcohol dependence.
white substance white matter.

con·trolled sub·stance

a substance subject to the U.S. Controlled Substances Act (1970), which regulates the prescribing and dispensing, as well as the manufacturing, storage, sale, or distribution of substances assigned to five schedules according to their 1) potential for or evidence of abuse, 2) potential for psychic or physiologic dependence, 3) contribution to a public health risk, 4) harmful pharmacologic effect, or 5) role as a precursor of other controlled substances.

controlled substance

(kən-trōld′)
n.
A drug or chemical substance whose possession and use are prohibited by or regulated under the federal Controlled Substances Act or an analogous state law.

controlled substance

Etymology: Fr, controle, to register; L, substantia, essence
any drug defined in the five categories of the federal Controlled Substances Act of 1970. The categories, or schedules, cover opium and its derivatives, hallucinogens, depressants, and stimulants. Schedule I drugs have a high abuse potential and no approved medical uses. Drugs in Schedules II to V all have approved medical indications, with decreasing abuse and dependence liabilities as the schedule number increases.

con·trolled sub·stance

(kŏn-trōld' sŭb'stăns)
A substance subject to the U.S. federal Controlled Substances Act (1970), which regulates the prescribing and dispensing, as well as the manufacturing, storage, sale, or distribution, of substances assigned to five schedules according to their: 1) potential for or evidence of abuse; 2) potential for psychic or physiologic dependence; 3) role in putting the health of the public at risk; 4) harmful pharmacologic effect; or 5) role as a precursor of other controlled substances.

con·trolled sub·stance

(kŏn-trōld' sŭb'stăns)
Substance subject to U.S. ControlledSubstances Act (1970), which regulates prescribing and dispensing, as well as manufacturing, storage, sale, or distribution of substances assigned to five schedules according to their 1) potential for or evidence of abuse, 2) potential for psychic or physiologic dependence, 3) contribution to a public health risk, 4) harmful pharmacologic effect, or 5) role as a precursor of other controlled substances.

controlled substance,

a drug as defined in the five categories of the federal Controlled Substances Act of 1970. The categories, or schedules, cover opium and its derivatives, hallucinogens, depressants, and stimulants.

substance

the material constituting an organ or body.

black substance
substantia nigra.
controlled substance
depressor substance
a substance that tends to decrease activity or blood pressure.
gray substance
nerve tissue composed of predominantly nerve cell bodies, unmyelinated nerve fibers, and supporting tissue. See also gray matter.
ground substance
the gel-like material in which connective tissue cells and fibers are embedded.
medullary substance
1. the white matter of the central nervous system, consisting of axons and their myelin sheaths.
2. the soft, marrow-like substance of the interior of such structures as bone, kidney and adrenal gland.
substance P
an undecapeptide present in the intestine, where it induces contraction of the intestine and dilatation of blood vessels; it is also present in a number of neuronal pathways in the brain and in primary sensory fibers of peripheral nerves, and may be a neurotransmitter associated with transmission of pain impulses.
perforated substance
1. anterior perforated substance, an area anterolateral to each optic tract, pierced by branches of the anterior and middle cerebral arteries.
2. posterior perforated substance, an area between the cerebral peduncles, pierced by branches of the posterior cerebral arteries.
pressor substance
a substance that raises blood pressure.
reticular substance
the netlike mass of threads seen in erythrocytes after vital staining.
slow-reacting substance
threshold s's
those substances (e.g. glucose) excreted into the urine only when their concentration in plasma exceeds a certain value.
white substance
tissue consisting mostly of myelinated nerve fibers and constituting the conducting portion of the brain and spinal cord; see also white matter.
References in periodicals archive ?
According to a statement issued by Drap Chairmen of Provincial Quality Control Boards of Punjab, Sindh, KP, Balochistan, Gilgit Baltistan and AJK have been asked to ensure strict compliance with the drug sales rules particularly related to the sales of medicines containing controlled substances.
This decision was made by the Committee for Allocation of Quota of Controlled Substances constituted under SRO in its meeting January 26.
Specifically, the complaint alleges that the distributors and pharmacies violated the Controlled Substances Act and DEA regulations by filling suspicious or invalid orders at the wholesale and retail level, failing to maintain effective controls against opioid diversion, failing to operate effective systems to identify and report suspicious orders of controlled substances, failing to maintain proper records of controlled substance transactions, and filling questionable or invalid prescriptions.
They just have to watch how many prescriptions they write for controlled substances and make sure they are legitimate prescriptions.
A programme has been launched by US pharmacy benefit manager Prime Therapeutics LLC (Prime), which serves 14 Blue Cross and Blue Shield plans nationally, that identifies members who are at risk of controlled substance misuse and gets them into programs that can help reduce their risk, the company said.
Due to the nature of controlled substances and the risks of prescription abuse, the certified e-prescribing of controlled substances requires several extra steps, including the electronic identification of each prescriber, a two-factor authentication process and an internal audit trail of prescriptions, among other things.
52) Likewise, as specified by the CSA, the misconduct mandating exclusion does not need to relate to controlled substances in order to provide the Administrator with the power to suspend or revoke a COR.
Controlled substances are generally understood to be drugs or substances whose use or misuse carries a substantial risk of harm.
Testing equipment used, intended for use, or designed for use in identifying, or in analyzing the strength, effectiveness, or purity of, controlled substances.
Drug discovery company AMRI (NasdaqGS:AMRI) revealed on Tuesday the receipt of approval from the US Drug Enforcement Administration (DEA) registration to expand its license to handle Schedule 2 and 2N controlled substances at its Burlington, Mass.
The development and manufacturing of controlled substances requires stringent controls and security measures," said Dan Childers, vice president of Quality Assurance and Regulatory Compliance.
or unusual usage patterns of controlled substances by patients and unusual prescribing or dispensing patterns by licensed practitioners;

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