The contrast agent
's molecular structure determines its stability and if it can be re-chelated by a given chelating agent.
The authors of another study concluded that [Gd.sup.3+]n-US-tube species are linear super paramagnetic molecular magnets with MRI efficacies 40-90 times higher than any current [Gd.sup.3+]-based contrast agent
in clinical usage.
She said: "Gadolinium contrast agents
are compounds that contain a very toxic heavy metal paired with a rather untested drug with variable stability, with somewhat unknown clinical benefits.
Sherry, "Advances in gadolinium-based MRI contrast agent
designs for monitoring biological processes in vivo," Current Opinion in Chemical Biology, vol.
The contrast agent
can cause adverse respiratory reactions such as overt bronchospasm, laryngeal oedema, cardiac failure and loss of consciousness, and  pulmonary oedema.
The iron concentration was chosen to match the recommended clinical dose of 0.56 mg of iron per kg used clinically for the SPIO contrast agent
Feridex[R] (Feridex IV, Berlex Laboratories).
Werneck, "Valsalva maneuver procedures in the diagnosis of right-to-left shunt by contrast-enhanced transcranial doppler using agitated saline solution with blood as a contrast agent
," Arquivos de Neuro-Psiquiatria, vol.
Conventional contrast agents
are directly injected into the body to make some tissues or diseases more clearly visible on MRI scans.
It is the first time a non-synthetic contrast agent
has been used in human magnetic resonance tomography examinations, and the results are promising.
In recent years, research on the use of ferrite nanoparticles in [T.sub.2] contrast agents
has shown a great potential application in MR imaging.
Another implicit assumption of the technique of DSCMRI related to the estimation of AIF is that no or a negligible amount contrast agent
penetrates the arterial wall, due to the fact that, in general, the vascular wall is considered irrelevant for the contrast mechanism in DSC-MRI.
"This study, using our iodinated contrast agent
, Visipaque, is significant and further proof of our commitment to our continued research in contrast media to improve patient care," said Jan Makela, General Manager, Core Imaging, GE Healthcare Life Sciences.