NOS1

(redirected from Constitutive NOS)

NOS1

A gene on chromosome 12q14-qter that encodes neuronal nitric oxide synthase (nNOS), a widely expressed enzyme that produces nitric oxide (NO). A messenger molecule with diverse functions throughout the body, nNOS plays a role in a wide range of physiological and pathological processes, including neurotransmission, neurotoxicity, muscle contraction, sexual function, fluid homeostasis and atherosclerosis.
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More interestingly, NO released from constitutive NOS activates COX-1, but iNOS selectively activates synthesis of COX-2-derived [PGE.
Constitutive NOS activity but not expression was significantly increased by in vitro exposure (72 hr) to melatonin.
Low levels of NO production typically result from constitutive NOS (cNOS) activity, with many associated physiological actions of this molecule resulting from the activation of guanylate cyclase and that enzyme's production of cyclic GMP (13).
1) Thus far, two forms of this enzyme have been identified: constitutive NOS (cNOS which is expressed constantly regardless of environmental conditions, and inducible (type 2) NOS (iNOS), which is expressed only as a reaction to endotoxins and inflammatory mediators.
Constitutive NOS can be classified according to its site of origin as either neuronal (type 1) NOS (nNOS) or endothelial (type 3) NOS (eNOS).
found that DEP exposure increased the level of constitutive NOS in the airway epithelium and inducible NOS in the macrophages of mice.
1998) observed that cigarette smoke specifically affected constitutive NOS activity.
A decrease in constitutive NOS (cNOS) activity and an increase in inducible NOS (iNOS) activity were determined in gastric damaged tissues induced by IND.
The intensities of the control and shear NOS I bands are identical at 6 h, indicating that cultured hASMC express a constitutive NOS I protein whose enzymatic activity, rather than the amount of protein, is modulated by shear stress.