Premarin

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Related to Conjugated estrogens: Premarin

estrogens, conjugated

C.E.S. (CA), Congest (CA), Premarin, Premarin Intravenous

Pharmacologic class: Estrogen

Therapeutic class: Replacement hormone, antineoplastic, antiosteoporotic

Pregnancy risk category X

Action

Bind to nuclear receptors in responsive tissues (such as female genital organs, breasts, and pituitary gland), enhancing DNA, RNA, and protein synthesis. In androgen-dependent prostate cancer, compete for androgen receptor sites, inhibiting androgen activity. Also decrease pituitary release of follicle-stimulating and luteinizing hormones.

Availability

Powder for injection: 25 mg/5 ml

Tablets: 0.3 mg, 0.625 mg, 0.9 mg, 1.25 mg

Vaginal cream: 0.625 mg/g

Indications and dosages

Ovariectomy; primary ovarian failure

Adults: 1.25 mg P.O. daily continuously or in cycles of 3 weeks on and 1 week off

Osteoporosis and menopausal symptoms

Adults: 0.3 to 1.25 mg P.O. daily continuously or in cycles of 3 weeks on and 1 week off

Female hypogonadism

Adults: 0.3 to 0.625 mg P.O. daily, given in cycles of 3 weeks on and 1 week off

Inoperable breast cancer in men and postmenopausal women

Adults: 10 mg P.O. t.i.d. for 3 months or more

Inoperable prostate carcinoma

Adults: 1.25 to 2.5 mg P.O. t.i.d.

Uterine bleeding caused by hormonal imbalance

Adults: 25 mg I.M. or I.V., repeated in 6 to 12 hours if necessary

Atrophic vaginitis, kraurosis vulvae

Adults: 0.5 to 2 g (vaginal cream) intravaginally daily in cycles of 3 weeks on and 1 week off

Moderate to severe dyspareunia

Adults: 0.5 g (vaginal cream) intravaginally daily in cycles of 3 weeks on and 1 week off

Contraindications

• Hypersensitivity to drug or its components
• Thromboembolic disease (current or previous)
• Undiagnosed vaginal bleeding
• Breast or reproductive system cancer (except metastatic disease)
• Estrogen-dependent neoplasms
• Pregnancy

Precautions

Use cautiously in:
• cardiovascular disease, severe hepatic or renal disease, asthma, bone disease, migraine, seizures, breast disease
• family history of breast or genital tract cancer
• breastfeeding patients.

Administration

• Know that drug is compatible with dextrose 5% in water and normal saline solution.

Adverse reactions

CNS: headache, dizziness, lethargy, depression, asthenia, paresthesia, syncope, cerebrovascular accident (CVA), seizures

CV: hypertension, chest pain, myocardial infarction (MI), thromboembolism

EENT: contact lens intolerance, worsening of myopia or astigmatism, otitis media, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, abdominal cramps, bloating, enlarged abdomen, dyspepsia, flatulence, gastritis, gastroenteritis, hemorrhoids, colitis, gallbladder disease, anorexia, pancreatitis

GU: urinary incontinence, dysuria, urinary tract infection, amenorrhea, dysmenorrhea, endometrial hyperplasia, vaginal candidiasis, leukorrhea, vaginal hemorrhage, genital eruptions, gynecomastia, breast tenderness, breast enlargement or secretion, reduced libido, erectile dysfunction, testicular atrophy, increased risk of breast cancer, endometrial cancer, hemolytic uremic syndrome

Hepatic: cholestatic jaundice, hepatic adenoma

Metabolic: hyperglycemia, hypercalcemia, sodium and fluid retention, reduced carbohydrate tolerance

Musculoskeletal: leg cramps, back pain, skeletal pain

Respiratory: upper respiratory tract infection, bronchitis, pulmonary embolism

Skin: acne, oily skin, pigmentation changes, urticaria, pruritus, erythema nodosum, hemorrhagic eruption, skin hypertrophy, hirsutism, alopecia, erythema multiforme

Other: edema, weight changes, increased appetite, hypersensitivity reaction, angioedema

Interactions

Drug-drug.Corticosteroids: enhanced corticosteroid effects

CYP450 inducers (such as barbiturates, rifampin): decreased estrogen efficacy Hypoglycemics, warfarin: altered requirement for these drugs

Phenytoin: loss of seizure control

Tamoxifen: interference with tamoxifen effects

Tricyclic antidepressants: reduced antidepressant effects

Drug-diagnostic tests.Antithrombin III, folate, low-density lipoproteins, pyridoxine, total cholesterol, urine pregnanediol: decreased values

Cortisol; factors VII, VIII, IX, and X; glucose; high-density lipoproteins; phospholipids; prolactin; prothrombin; sodium; triglycerides: increased values

Metyrapone test: false decrease

Thyroid function tests: false interpretation

Drug-food.Caffeine: increased caffeine blood level

Drug-herbs.Black cohosh: increased risk of adverse reactions

Red clover: interference with estrogen effects

Saw palmetto: antiestrogenic effects St. John's wort: decreased drug blood level and effects

Drug-behaviors.Smoking: increased risk of adverse cardiovascular reactions

Patient monitoring

• Monitor liver function test results and assess abdomen for enlarged liver.
• Evaluate patient for breast tenderness and swelling. As needed, give analgesics and apply cool compresses.
• Monitor fluid intake and output, and weigh patient daily.

Know that drug increases risk of thromboembolism, CVA, and MI.
• Be aware that exogenous estrogens may induce or exacerbate symptoms of angioedema, particularly in women with hereditary angioedema.
• Check serum phosphatase level in patients with prostate cancer.
• Monitor calcium, glucose, and folic acid levels.
• Evaluate bone density annually.

Patient teaching

Teach patient to recognize and report signs and symptoms of thromboembolism.

Caution patient not to take drug if she is or plans to become pregnant.
• Tell patient to report breakthrough vaginal bleeding.
• Recommend that patient have routine breast examinations.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

Premarin

(prĕm′ə-rĭn′)
A trademark for a drug preparation of conjugated estrogens.

Premarin

a trademark for conjugated estrogens.

Premarin®

Gynecology An estrogen conjugate obtained from pregnant horse mare urine commonly used as a hormone-replacement in postmenopausal ♀, to relieve the Sx of menopause–eg, hot flashes, osteoporosis, vaginal atrophy, etc Adverse effects Dizziness, lightheadedness, stomach upset, bloating or nausea, severe depression, calf pain, sudden severe headache, chest pain, SOB, lumps in breast, weakness or tingling in the arms or legs, dysmenorrhea

Premarin

A brand name for a preparation of conjugated oestrogens. The name is said to derive from the source-pregnant mare's urine.
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April 11 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth , reports that data published today in the Journal of the American Medical Association (JAMA) showed that in the estrogen-alone sub-study of the Women's Health Initiative (WHI), conjugated estrogens 0.
Biochemical markers of bone metabolism and vertebral bone density also were evaluated in another longitudinal, 2-year study that compared calcium supplementation alone (500 mg/day) with three combination regimens: standard-dose ipriflavone (600 mg/day) plus calcium; low-dose conjugated estrogens (0.
A history of taking only combined hormone replacement therapy (CHRT)--primarily conjugated estrogens with medroxyprogesterone acetate--was associated with a 2.
The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.
The District Court decision instructed Natural Biologics to withdraw its Drug Master File (DMF) for equine-based conjugated estrogens raw material from the U.
We filed this complaint to eliminate the perpetuation of Premarin's(R) monopoly that has denied American women and their physicians access to Cenestin, a high-quality conjugated estrogens product," said Duramed chairman and chief executive officer E.
Court Also Affirms Decision to Permanently Enjoin Natural Biologics from Making or Selling Any Conjugated Estrogens Product -
Food and Drug Administration (FDA) approval for its New Drug Application (NDA) for Enjuvia(TM) (synthetic conjugated estrogens, B) 0.