congenital rubella syndrome

(redirected from Congenital rubella)


a mild systemic disease caused by a virus and characterized by a fever and a transient rash. It is not as contagious as chickenpox or measles, but there are frequent epidemics among schoolchildren, usually during the spring and early summer. The virus is spread by direct contact and by droplet infection. Rubella begins with a slight cold, fever, and sore throat. The lymph nodes behind the ears and at the back of the neck may swell, causing soreness or pain when the head is moved. The rash appears first on the face and scalp, and spreads to the body and arms the same day; it is similar to the rash of measles, although the spots usually do not run together. It fades after 2 or 3 days, although in a few cases the disease may last as long as a week. Called also German measles and three-day measles

If a pregnant woman contracts rubella, especially during the first trimester, the virus can damage the developing offspring. The location and extent of the resulting congenital anomaly are determined in large part by the developmental stage of the embryo at the time of the attack. Congenital heart defects, cataracts, mental retardation, and deafness are some of the more common defects resulting from maternal rubella.
Treatment and Prevention. Except for complications that may result if the disease is contracted during pregnancy, other complications are rare. No special treatment, medicine, or diet is necessary unless the patient has a high fever. One attack usually gives lifetime immunity to the disease, although a second attack does occasionally occur. The Centers for Disease Control and Prevention recommends two doses of rubella vaccine for all children, given as combination measles-mumps-rubella vaccine, with doses at least four weeks apart. The first dose should be given when the child is 12 months old. Vaccine is also recommended for susceptible nonpregnant adolescents and adults who do not have rubella immunity.
Congenital rubella syndrome is marked by a triad that includes microcephaly, microphthalmia, and congenital heart disease. From Damjanov, 2000.
congenital rubella syndrome (rubella syndrome) transplacental infection of the fetus with rubella usually in the first trimester of pregnancy, as a consequence of maternal infection (which may or may not be clinically apparent), resulting in various developmental abnormalities in the newborn infant. They include cardiac and ocular lesions, deafness, microcephaly, mental retardation, and generalized growth retardation, which may be associated with acute self-limited conditions such as thrombocytopenic purpura, anemia, hepatitis, encephalitis, and radiolucencies of long bones. Infected infants may shed the virus to all contacts for extended periods of time.

con·gen·i·tal ru·bel·la syn·drome

fetal infection with rubella virus during the first trimester of pregnancy resulting in a series of congenital abnormalities including heart disease, deafness, and blindness.

congenital rubella syndrome

a collection of birth defects caused by transmission of the rubella virus from an infected mother to a fetus during the first trimester of pregnancy. Anomalies include cataracts, congenital heart disease, and sensorineural hearing loss. The infant may be small for gestational age and exhibit hyperbilirubinemia, thrombocytopenia, and hepatomegaly.
enlarge picture
Congenital rubella syndrome: hyperpigmentation and hypopigmentation of the retina

congenital rubella syndrome

A malformation complex in a fetus infected in utero with rubella; the defects reflect the embryologic stage at the time of infection, with developmental arrest affecting all 3 embryonal layers, inhibiting mitosis, causing delayed and defective organogenesis; maternal infection in the 1st 8 wks of pregnancy causes embryopathy in 50-70% of fetuses; the susceptible period extends to ±20th wk; infection in late pregnancy carries little fetal morbidity Clinical Cardiac defects–eg PDA, pulmonary valve stenosis, VSD, hepatosplenomegaly, interstitial pneumonia, LBW, congenital cataracts, deafness, microcephaly, petechia, purpura, CNS Sx–eg, mental retardation, lethargy, irritability, dystonia, bulging fontanelles, ataxia Lab Viral isolation, IgM antibodies in fetus by hemagglutination inhibition Vaccination Attenuated live virus vaccine between 15 months and puberty; effective antibodies develop after immunization in 95% of Pts. See Extended rubella syndrome.
References in periodicals archive ?
Albeit it causes mild illness in children, it can have major effects in pregnant women, resultinn in foetal death or defects called as congenital rubella syndrome (CRS).
Guidelines for the documentation and verification of measles, rubella, and congenital rubella syndrome elimination in the region of the Americas.
During an April meeting of the International Expert Committee for Measles and Rubella Elimination in the Americas, members concluded that there was no evidence of endemic transmission of rubella or congenital rubella syndrome for five consecutive years, exceeding the typical three-year requirement for designating a disease as eliminated.
My wife's cousin cares for her middle-aged son, who has congenital rubella and cataracts and is deaf and mentally disabled.
The founders of Sense were parents whose children were born deafblind as a result of congenital rubella syndrome and we believe that urgent action is needed to prevent outbreaks of rubella, as well as measles.
By Noimot Olayiwola/ Staff Reporter The Supreme Council of Health is aiming to eradicate measles and congenital rubella syndrome from Qatar by 2015, it was announced yesterday.
Then, as an adult, I worked on a longitudinal study in the 1960s of the behavioral effects of congenital rubella (that eventually led to a book cited by Reagan: Stella Chess, Sam J.
Chris is a 40-year-old woman who is deaf-blind as a result of congenital rubella syndrome.
She met another parent, Margaret Brock MBE, whose son was similarly born with Congenital Rubella Syndrome and together they formally set up the first parents' Rubella Group in 1955.
5 in 1 million Source: Centers for Disease Control and Prevention MMR Vaccine Data Disease Deaths Other Complications Measles 2 in 1,000 pneumonia, 6 in 100 encephalitis, 1 in 1,000 Rubella - congenital rubella syndrome, 1 in 4 if infected early in pregnancy Vaccine Deaths Other Complications MMR _ encephalitis or severe allergic reaction, I in 1 million Source: Centers for Disease Control and Prevention
Her transformation has been so dramatic that Maureen, who has congenital rubella syndrome, is now in the running to be crowned 'Deafblind Person of the Year' at Sense charity's annual awards.
For 55 years Sense has supported deafblind people with congenital rubella syndrome and we know all too well the dangers of not taking the MMR vaccine.

Full browser ?