Craik and colleagues have based their findings on conotoxins, the small proteins contained in cone snail
venom that have long been known for its pain relieving properties.
Researchers from 13 European countries, including a team from Strathclyde University, are among those taking part in the Cone Snail
Genome Project for Health.
The cone snail
toxin blocks the neuromuscular junction, even in minute quantities.
Not to mention the beautiful but venomous cone snail
which has come up with a spider-like solution to how such a slow-moving creature can hope to catch its prey - by injecting it with a cocktail of about a dozen small toxic compounds.
A deadly poison, emitted by the cone snail
, is holding out hope for suffers of chronic pain, epilepsy and neurological disorders.
Researchers at the company are studying the development of novel, highly efficacious drugs with minimal side effects based on the Cone Snail
William Brose and was derived from the venom of a killer sea snail, the cone snail
The final section, on peptide toxins, contains a review of the work on conotoxins, the biologically active peptides in cone snail
venom; sea anemone polypeptide toxins that affect sodium channels; and chapters on sea snake venom (neurotoxins), the cytolytic peptides found in sea anemones, some natural jellyfish toxins, plus an article on pardaxin, the neurotoxic polypeptide from the Red Sea Moses sole, Pardachirus marmoratus, which targets gills and pharynx of aquatic animals and is eyed as a shark repellant.
Peptides like those in cone snail
venom block excitatory ion channels in the neurons that transmit pain signals to the brain without affecting the brain itself, and thus do not produce tolerance or addiction or affect mental acuity.
She and colleagues found the insulin during a standard screen of venom genes from two cone snail
species (Conus geographus and C.
RiffTrax takes on the honey badger, mantis shrimp and geographer's cone snail
of Bad@$$ Animals .
Washington, Mar 17 ( ANI ): Scientists have created at least five new experimental substances, based on a tiny protein found in cone snail
venom, that could someday lead to the development of safe and effective oral medications for treatment of chronic nerve pain.