endometrial hyperplasia

(redirected from Complex hyperplasia)

endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
Farlex Partner Medical Dictionary © Farlex 2012

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
2 cases (0.9%) were reported as complex hyperplasia. Rather GR et al [10] found 1.14% each of disordered proliferative endometrium and complex hyperplasia and a bit higher incidence of simple hyperplasia (3.29%).
[H] mass under atypia, or Isparta, Turkey general malignancy anesthesia Caschetto Total abdominal Complex hyperplasia et al.
Table 1: Distribution of cases of AUB according to histological pattern Histological diagnosis Total number of cases (N=1545) (%) Proliferative phase 117 (7.6) Secretory phase 372 (24.1) Products of conception 62 (4.0) Simple hyperplasia without atypia 350 (22.6) Complex hyperplasia without atypia 42 (2.7) Hyperplasia with atypia 03 (0.2) Endometrial polyps 127 (8.2) Atrophic endometrium 52 (3.4) Hydatidiform mole 75 (4.9) Irregular ripening of endometrium 301 (19.5) Endometritis 13 (0.8) Endometrial carcinoma 28 (1.8) Choriocarcinoma 03 (0.2) Total 1545 (100)
Women with a BMI [greater than or equal to] 30 kg/[m.sup.2] were 4 times more likely to develop complex hyperplasia or cancer than normalweight women.
Morphological changes in endometrium of infertile women included; secretory phase in 102(63.75%), disordered proliferative endometrium in 28(17.5%), irregular maturation endometrium in 11(6.8), proliferative endometrium in 8(5%) complex hyperplasia in 6(3.7%), simple hyperplasia in 3(1.8%) and discordance between glands and stroma in 2(1.2%) cases.
Among endometrial hyperplasia, 23 cases (6.1%) were of simple cystic hyperplasia, 5 cases (1.3%) were complex hyperplasia without atypia and 4 cases (1.1%) were complex hyperplasia with atypia.
Dilatation and curettage under hysteroscopy were performed in 6 patients before surgery, and pathology revealed 2 cases of endometrioid carcinoma, 3 cases of endometrial atypical hyperplasia not exclusive of carcinoma, and 1 case of complex hyperplasia. All the 10 patients were found to have adenomyosis by pathological examination after surgery, and atypical glandular epithelial hyperplasia was found at the adenomyosis focus.
A study22 analysed 2295 endometrial samples from women presenting with AUB from January 1995 to June 2008 and noted that the commonest histopathological diagnosis was secretory endometrium in 571(24.9%) cases, followed by proliferative endometrium in 498(21.7%), endometrial polyp in 227(9.9%), disordered proliferative endometrium in 200(8.7%), simple cystic hyperplasia in 160(7%), chronic endometritis in 134(5.8%), inactive endometrium in 126(5.5%), atrophic endometrium in 70(3.1%), uterine malignancies in 41(1.8%), complex hyperplasia without atypia in 33(1.4%) and finally complex hyperplasia with atypia in 15(0.7%) cases.
In comparison to the four categories (simple hyperplasia, complex hyperplasia, simple hyperplasia with atypia, and complex hyperplasia with atypia) that comprise the World Health Organization (WHO) 1994 classification system, proponents of the BH/EIN classification system have shown improved reproducibility in the diagnostic setting.
However, 5 of the 6 cases were simple hyperplasia with no atypia and only 1 case of complex hyperplasia and again no atypia.
The authors analysed Rb2/p130 expression by immunohistochemistry staining in 102 specimens chosen to represent a spectrum of endometrial changes, including proliferative endometrium (n = 18), secretory endometrium (n = 18), simple or complex hyperplasia without atypia (n = 18), atypical hyperplasia (n = 18), and invasive carcinoma (n = 30).
Endometrial biopsies in 36 patients on mifepristone found endometrial hyperplasia in 28% with no cases of complex hyperplasia or cytologic atypia, said Dr.

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