complementation group


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complementation group

a collection of MUTANT ALLELES that fails to complement and restore the WILD TYPE when tested in all pair-wise combinations (see CIS-TRANS TEST). The complementation group is initially used to define the basic genetic unit of function or CISTRON (now synonymous with GENE).
References in periodicals archive ?
4) Hearing loss -- 19/159 (11) FA = Fanconi anaemia; FANCA = FA, complementation group A.
2004) Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.
47 * Abbreviations: FANCC, Fanconi anemia complementation group C; UBC13, ubiquitin-conjugating enzyme 13.
FA can be divided into 12 complementation groups (A, B, C, D1, D2, E, F, G, I, J, L and M) defined by cell fusion studies and 11 of the 12 responsible FA genes have been identified [11-13].
6-8 It is reported that xeroderma pigmentosum (XP) complementation groups in human, XPA to XPG, represent the ratelimiting proteins in the NER pathway.
6 Several XP complementation groups, XPA to XPG, have been identified, which represent the rate-limiting proteins in the NER mechanism.
Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
Additionally, a particular tumor may be assigned to any of the four senescence complementation groups, independent of its tissue of origin.
There is genetic heterogeneity identified by somatic cell fusion studies or complementation groups.
Genetic Analysis of Indefinite Division in Human Cells: Identification of Four Complementation Groups," Proceedings of the National Academy of Sciences 85:6042-6046, 1988.
Myles and Sancar's comprehensive 1989 review on DNA Repair pre-dates the recent breakthroughs in cloning the human genes for Fanconi's anemia and several of the xeroderma pigmentosum complementation groups (reviewed by Barnes, Nature 359: 12-13, 1992).