complementarity determining regions

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com·ple·men·tar·i·ty de·ter·min·ing re·gions

that part of an antibody or T cell receptor variable region that binds with antigen or antigen/major histocompatibility molecule (that is, antigen-combining region).
References in periodicals archive ?
The sequence of the peptide is based on the complementarity determining region 1 (CDR1) of a pathogenic human anti-DNA monoclonal antibody (mAb) that bears the 16/6 idiotype (16/6 Id)1.
The subject of this patent is his discovery that the TCR second complementarity determining region (CDR2) can provide vaccines having greater selectivity and potency for the larger numbers of patients.
An antibody-based biomarker discovery method by mass spectrometry sequencing of complementarity determining regions.
Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.
The variable regions are comprised of engineered complementarity determining regions (CDRs) supported by fully human frameworks derived from germline genes.
The antibodies can be made by grafting of the complementarity determining regions of mouse monoclonal antibody to human 4-1BB to the remaining portions of a human antibody and by making further amino acid replacements.
The complementarity determining regions or CDRs, of an antibody are responsible for high-affinity binding.
The complementarity determining regions, or CDRs, of an antibody are responsible for high-affinity binding.

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