'We continued to advance our complement factor
D inhibitors in the second quarter of 2019 by efficiently executing on our global development and regulatory strategies, while continuing to strengthen our intellectual property position.
The purpose of this study is to investigate the safety and efficacy of IFX-1, a first-in-class anti-human complement factor
C5a monoclonal antibody, in patients suffering from moderate to severe Hidradenitis Suppurativa (HS), a painful and debilitating chronic inflammatory skin disease with limited treatment options.
An alternative pathway of the complement system is activated by the self-hydrolysis of complement C3, which promotes the binding of the b subunit of C3 to the b subunit of complement factor
B (CFB) to produce a membrane attack complex (9).
The researchers also studied how different gene variants of the C4 gene (complement factor
4) affect the pruning.
Pursuant to the agreement, argenx has selected a second target from Halozyme under the latter's ENHANZE Technology.The second target selected for development by argenx is human complement factor
C2 associated with the product candidate ARGX-117, which is being developed to treat severe autoimmune diseases.
An intriguing finding in our study was direct and inverse correlations between amyloid [beta] peptide and complement factor
To date, some gene polymorphisms have been identified for the vasculature- or inflammation-related pathogenesis of SD, such as protein kinase C-eta 1425G/A, matrix metalloproteinase-1 1607G/2G, methylenetetrahydrofolate reductase 677C/T, prothrombin 20210G/A, platelet Gly IIIaA1/A2, factor V Leiden 1691G/A, interleukin-1A-889C/T, interleukin-6C 572C/G, complement factor
H 402Y/H, and nitric oxide synthase 3 894G/T polymorphisms [4-13].
Finally, neuroglia express inhibitory protective molecules to prevent uncontrolled complement-mediated damage, such as CD59, complement factor
H (CFH), and complement receptor-related protein-y (Crry), which mainly interfere with C3 [19, 117].
Of the 102 cytokines assessed, the array showed increased expression of 21 proteins in the cocultured samples: adiponectin, chitinase 3-like 1, complement factor
D, CXCL5, endoglin/CD105, IGFBP-3, IL-4, IL-6, IL-16, IL-23, IL-24, IL-33, leptin, LIF, myeloperoxidase, osteopontin, pentraxin-3, CCL5/RANTES, serpinE1, CCL17/TARC, and uPAR.
A genetic screening of the alternative complement pathway revealed a heterozygous mutation in complement factor
I (CFI) gene c.148C>G (p.(Pro50AIa)), associated with a heterozygous variant of membrane cofactor protein CD46 (c-366A) and a homozygote deletion of complement factor
H (CFH) related protein CFHR1 and CFHR3 genes.
Farrer, "Complement factor
H polymorphism and age-related macular degeneration," Science, vol.
9,796,741, entitled "Aryl, Heteroaryl, and Heterocyclic Compounds for Treatment of Complement Mediated Disorders," has been granted with claims to compositions of matter for ACH-4471 and additional compounds that inhibit complement factor
D activity, a key mediator in the complement alternative pathway (AP).