complement system

(redirected from Complement 5A)

com·ple·ment sys·tem

a group of more than 20 serum proteins, some of which can be serially activated and participate in a cascade resulting in cell lysis; the complement system also functions in chemotaxis, opsonization, and phagocytosis.
References in periodicals archive ?
He then discussed about AAV novel therapies and mentioned about complement 5a EGPA therapy.
ChemoCentryx announced presentations of its lead drug candidates avacopan, a complement 5a receptor inhibitor, and CCX140, an inhibitor of the chemokine receptor known as CCR2, during the American Society of Nephrology, ASN, Kidney Week 2018, the world's premier nephrology meeting, being held October 23-28 in San Diego.
Avacopan (CCX168) is an orally-administered inhibitor of the complement 5a receptor (C5aR) being developed by ChemoCentryx for the treatment of orphan and rare renal diseases, including but not limited to, anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV).
Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.