Also found in: Dictionary, Thesaurus.
Related to Compazine: Phenergan, prochlorperazine, Haldol


trademark for preparations of prochlorperazine, an antipsychotic agent and antiemetic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Compazine (CA), Compro, Stemetil (CA)

prochlorperazine edisylate

Compazine (CA)

prochlorperazine maleate

Buccastem (UK), Compazine (CA), Proziere (UK), Stemetil (CA) (UK)

Pharmacologic class: Phenothiazine

Therapeutic class: Antiemetic, antipsychotic, anxiolytic

Pregnancy risk category C


Exerts anticholinergic, CNS depressant, and antihistaminic effects. Depresses release of hypothalamic and hypophyseal hormones, decreases sensitivity of middle-ear labyrinth, and reduces conduction in vestibular-cerebellar pathways.


Capsules (extended-release, maleate): 10 mg, 15 mg, 30 mg

Injection (edisylate): 5 mg/ml

Oral solution (edisylate): 5 mg/5 ml

Suppositories: 2.5 mg, 5 mg, 25 mg

Tablets: 5 mg, 10 mg, 25 mg

Indications and dosages


Adults: 5 to 10 mg P.O. three to four times daily or 15 mg P.O. once daily or 10 mg P.O. (extended-release) b.i.d., up to 40 mg/day. Or 2.5 to 10 mg I.V., not to exceed 40 mg/day.

Children weighing 18 to 38 kg (40 to 85 lb): 2.5 mg P.O. or P.R. t.i.d. or 5 mg P.O. or P.R. b.i.d., not to exceed 15 mg/day

Children weighing 13.6 to 17.7 kg (30 to 39 lb): 2.5 mg P.O. or P.R. two or three times daily, not to exceed 10 mg/day

Children weighing 9 to 13 kg (20 to 29 lb): 2.5 mg P.O. or P.R. daily to b.i.d., not to exceed 7.5 mg/day

Nausea and vomiting related to surgery

Adults: 5 to 10 mg I.V. 15 to 30 minutes before anesthesia induction, repeated once if necessary; or 5 to 10 mg I.M. 1 to 2 hours before anesthesia induction, repeated once in 30 minutes if necessary


Adults and children older than age 12: For mild symptoms, 5 to 10 mg P.O. three to four times daily; for moderate to severe symptoms in hospitalized or supervised patients, 10 mg P.O. three to four times daily, increased p.r.n. q 2 to 3 days to 50 to 75 mg P.O. daily or up to 150 mg/day as tolerated p.r.n. for more severely disturbed patients. Or 10 to 20 mg I.M.; may repeat q 2 to 4 hours for up to four doses p.r.n.

Children ages 2 to 12: Initially, 2.5 mg P.O. or P.R. two or three times daily (maximum of 10 mg on day 1); then increase based on response. Don't exceed 25 mg/day for children ages 6 to 12 or 20 mg/day for children ages 2 to 5.


Adults and children older than age 12: 5 mg P.O. three to four times daily; or 15 mg P.O. (extended-release) once daily or 10 mg P.O. (extended-release) q 12 hours; up to 20 mg/day for a maximum of 12 weeks

Off-label uses

• Migraine


• Hypersensitivity to drug or other phenothiazines

• Coma

• Concurrent use of large amounts of CNS depressants

• Pediatric surgery

• Children younger than age 2 or weighing less than 9 kg (20 lb)


Use cautiously in:

• cardiovascular or hepatic disease, glaucoma, seizures

• anticipated exposure to extreme heat

• children with acute illness.


• For I.V. infusion, dilute 20 mg in 1 L of compatible I.V. solution, such as normal saline solution.

• Don't mix in same syringe with other drugs.

• Know that injection solution may cause contact dermatitis. Don't get it on hands or clothing.

Give I.V. by slow infusion only. Don't give as bolus.

• Know that I.M. injection is not preferred because it can cause local irritation. However, if I.M. route is prescribed, inject deep into upper outer quadrant of gluteal area.

• Don't give by subcutaneous route.

• After desired response, switch to P.O. form as prescribed.

• When infusing I.V., watch for hypotension. Keep patient supine for 30 minutes after infusion.

Adverse reactions

CNS: sedation, extrapyramidal reactions, tardive dyskinesia, neuroleptic malignant syndrome

CV: orthostatic hypotension, ECG changes, tachycardia

EENT: blurred vision, lens opacities, pigmentary retinopathy, dry eyes

GI: constipation, ileus, dry mouth, anorexia

GU: pink or reddish-brown urine, urinary retention, galactorrhea

Hematologic: agranulocytosis, leukopenia

Hepatic: cholestatic jaundice, hepatitis Metabolic: hyperthermia

Skin: photosensitivity, pigmentation changes, rash

Other: allergic reactions


Drug-drug. Anticonvulsants: reduced seizure threshold

Antineoplastics: masking of antineoplastic toxicity

CNS depressants (including antihistamines, anticholinergics, opioids, other phenothiazines, sedative-hypnotics): additive CNS depression

Guanethidine: inhibition of antihypertensive effects

Oral anticoagulants: decreased anticoagulant effect

Phenytoin: increased or decreased phenytoin blood level Propranolol: increased blood levels of both drugs

Thiazide diuretics: increased risk of orthostatic hypotension

Drug-diagnostic tests. Liver function tests: abnormal results

Phenylketonuria test: false-positive result

Drug-herbs. Betel nut: increased risk of extrapyramidal reactions

Evening primrose oil: increased risk of seizures

Kava: increased risk of drug-related adverse reactions

Drug-behaviors. Alcohol use: additive CNS depression

Patient monitoring

Monitor neurologic status, especially for signs and symptoms of neuroleptic malignant syndrome (high fever, sweating, unstable blood pressure, stupor, muscle rigidity, and autonomic dysfunction).

• In long-term therapy, assess for other adverse CNS effects, including extrapyramidal symptoms and tardive dyskinesia.

• Monitor patient closely if he's receiving drug for nausea and vomiting associated with chemotherapy, because it may mask symptoms of chemotherapy toxicity.

• Evaluate CBC and liver function tests.

Patient teaching

• Instruct patient to dilute oral solution with tomato or fruit juice, milk, coffee, soda, tea, water, or soup.

Teach patient to recognize and immediately report signs and symptoms of an allergic reaction or neuroleptic malignant syndrome.

• Inform patient about drug's other CNS effects. Tell him to contact prescriber if these occur.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, alertness, and motor skills.

• Tell patient drug may turn urine pink or reddish brown.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug prochlorperazine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Prochlorperazine, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A trade name for PROCHLORPERAZINE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Zofran comes in an oral disintegrating tablet that, like Compazine, is useful in patients who have difficulty swallowing or who do not feel they are able to drink.
Przygoda had prescribed Compazine on two successive days when, in fact, the initial amount of Compazine would have lasted at least four days.
The company has introduced several products after their abbreviated new drug applications (ANDAs) won approval from the Food and Drug Administration, including meloxicam tablets (a generic version of Mobic), ascomp with codeine (generic version of Fiorinal with codeine), methylprednisolone (generic version of Medrol), prochlorperazine (generic version of Compazine), butalbital, acetaminophen, caffeine and codeine phosphate (generic version of Fioricet with Codeine), and folic acid, 1 mg.
Much of the data come from their use in treating nausea, particularly with prochlorperazine (Compazine).
Other common oral medications for NVP include prochlorperazine (Compazine), metoclopramide (Reglan), trimethobenzamide (Tigan), promethazine (Phenergan), and ondansetron (Zofran).
He was seen by the nephrologist rounding at the center and was instructed to take Imodium and Compazine as needed for presumed gastroenteritis.
Nausea may be mitigated if the drug is taken with food; if severe, it maybe treated with ondansetron (Zofran) or prochlorperazine (Compazine).
Phenergan, Tigan, Compazine, Torecan, Reglan, Propulsid, Trans-Scop, Antivert/Bonine, Marezine
insomnia, and loss of memory: Ativan Nembutal Lanoxin Butalan Noludar Procan Centrax Restoril Aldomet Dalmane Serax Catapres Luminal Tranxene Benadryl Halcion Valium Compazine Librium Xanax Zantac Limbitrol Haldol
The company has introduced several abbreviated new drug applications (ANDAs), including Ascomp with codeine, a generic version of Novartis Pharmaceuticals Corp.'s pain reliever Fiorinal with codeine; methylprednisolone, a generic equivalent to Pharmacia's antiinflammatory drug Medrol; prochlorperazine, the generic version of GlaxoSmithKline PLC's Compazine; butalbital, acetaminophen, caffeine and codeine phosphate, the generic version of Novartis' Fioricet with codeine; and folic acid, 1 mg.
* Prochlorperazine (Compazine) has been the subject of several studies, alone and in combination with dihydroergotamine (DHE) and naratriptan.
Prochlorperazine (Compazine) is more effective than ketorolac (Toradol) in the treatment of children presenting to the emergency department with migraine.