comparative genomic hybridization

(redirected from Comparative Genomic Hybridisation)
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comparative genomic hybridization

a cytogenetic technique in which reference DNA and the DNA to be studied, as from a tumor or an embryo, are labeled with green- and red-fluorescing fluorochromes, respectively. Genetic abnormalities are detected by changes in the green-to-red ratio.
References in periodicals archive ?
Detection of chromosomal imbalances in children with idiopathic mental retardation by array based comparative genomic hybridisation (array-CGH).
Computer image analysis of comparative genomic hybridisation.
High-resolution analysis of DNA copy number variation using comparative genomic hybridisation to microarrays.
Array-based comparative genomic hybridisation for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma.
Combined array comparative genomic hybridisation and tissue microarray analysis suggest PAK1 at 11q13.
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridisation.
From amplification to gene in thyroid cancer: a high resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genomic hybridisation.
The trial evaluated the BRCAplus panel, which combines next-generation sequencing with array comparative genomic hybridisation, to deliver mutation analysis in six high-risk genes, including BRCA1, BRCA2, PTEN, TP53, CDH1 and STK11.
Array comparative genomic hybridisation provides the tools to scan foetal DNA quickly and automatically to identify copy number variation, which indicates the deletion or addition of genetic material at a particular point on the genome.
The comparative genomic hybridisation technique identifies eggs with the best chance of being successfully implanted in the womb.
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