combinatorial chemistry


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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
References in periodicals archive ?
This review provides an introduction to combinatorial chemistry and its application to organic coating development.
It is uniquely suitable for the hydrogenation of large numbers of small samples for combinatorial chemistry. The pre-loaded column uses a minimum amount of catalyst, which avoids direct contact pre- or post-reaction.
The increasing complexity of combinatorial chemistry procedures and related measurements will boost opportunities for complementary software.
In the mid-1990s, combinatorial chemistry, which allows chemists to synthesise hundreds of chemical variants of some basic molecule, was emerging as a promising new approach to drug synthesis.
Under terms of the agreements, 3DP is using its DiscoverWorks drug discovery platform, which integrates high- throughput screening, combinatorial chemistry, chemi-informatics and structure-based drug design, to assist Bristol-Myers Squibb in the discovery and development of new human drugs for specific biological targets.
The technique, combinatorial chemistry, employs the rapid use of small-scale instrumentation to evaluate environmentally friendly processing methods.
(Plastics now exceed metals in order of importance to the economy, by some measures.) Consequently, there is no one "generic" plastics program and, to explore the value of combinatorial chemistry, it was first necessary to define the context of the development program.
Nowhere is the influence of molecular understanding felt as strongly as in the realm of drug discovery, where the drug screening procedure is made faster, cost-effective and productive by resorting to a novel concept in chemistry known as combinatorial chemistry [2,3,4].
At Agouron, state-of-the-art molecular biology, x-ray, crystallography, organic synthesis, biochemistry, computational chemistry, and combinatorial chemistry coverage on the challenge of drug design and discovery.
An update of the previous version (1.0), the "Database of Palladium Chemistry CD-ROM Version 1.1" contains 3850 reactions, 87 types of mechanisms, and includes papers using combinatorial chemistry. It is easily accessible and can be searched from the point of view of the reagents, the reaction products, or the underlying mechanism.
The beetle's tactic of producing large numbers of closely related chemicals is also used by pharmaceutical chemists, who thought they had invented the process, which they call combinatorial chemistry.
(I suspect the rage for alternative medicine is itself driven at least in part by the fact that such treatments are available without a prescription; the desire for self-reliance precedes the anti-technology ideology.) Science lovers dislike the way it squeezes out small-scale research on ideas like combinatorial chemistry - ideas that could address such problems as drug-resistant strains of tuberculosis.

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