combinatorial chemistry

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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
References in periodicals archive ?
Additionally, CombiChem has established two 50%-owned joint ventures.
Dispensette Organic Bottletop Dispensers use proven floating piston mechanism, but also employ new materials that offer better long term compatibility with certain organic solvent and concentrated acids, Ideal for HPLC and combichem laboratories, the dispenser is offered in analog and digital models.
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Ideal for HPLC and Combichem labs, dispenser is offered in analog and digital models.
Also featured is diverse selection of microplates for disciplines such as sample preparation, genomics, high throughput screening, CombiChem and solid phase extraction.