combinatorial chemistry

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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.
Farlex Partner Medical Dictionary © Farlex 2012

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Using its proprietary Discovery Engine(TM) process, CombiChem focuses on the generation, evolution, and optimization of new lead candidates for its collaborative partners, who will then develop, manufacture, market, and sell the resulting products.
From 1996-1999 was president and CEO of CombiChem Inc., a biotechnology company.