colony-stimulating factors

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colony-stimulating factors (CSF),

a group of glycoprotein growth factors regulating differentiation of myeloid cells. These substances act in either paracrine or autocrine fashion on marrow cells; appear to act synergistically in complex and poorly understood ways; each seems to have the ability to exert action on several lines of progenitor cells, and to influence end cell function.

col·o·ny-stim·u·lat·ing fac·tors

(CSF) (kol'ŏ-nē-stim'yū-lāt-ing fak'tŏrz)
A group of glycoprotein growth factors regulating differentiation in myeloid cell lines.


a discrete group of organisms, as a single cluster of bacteria in a culture that was produced from a single starting bacterium.

colony-forming units
colonies of pluripotent stem cells located and quantified in the spleen. Colonies grown in vitro interact with erythropoietin to give rise to morphologically identifiable erythroid cells.
colony-stimulating factors
cytokines produced by lymphocytes and mononuclear phagocytes which stimulate the growth and differentiation of hematopoietic cells. Includes granulocyte-macrophage colony-stimulating factor, monocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.
References in periodicals archive ?
Neuroprotective effects of granulocyte colony-stimulating factor and relationship to promotion of angiogenesis after spinal cord injury in rats: laboratory investigation.
Granulocyte colony-stimulating factor (G-CSF) is a naturally occurring hormone that is produced by the body to stimulate the bone marrow to produce neutrophils, a type of white blood cell that helps the immune system fight infection.
Direct medical costs -- as sourced by United Kingdom (UK) National Health Service (NHS) casemix data and UK national drug prices -- of key investigator-determined drug-related adverse events were reported for these two treatment groups, including hospitalizations, transfusions, erythropoietin, granulocyte colony-stimulating factors (GCSFs) and parenteral (injectable) antibiotics - commonly used supportive care for adverse events.