DPYSL3

(redirected from Collapsin response mediator protein 4)

DPYSL3

A gene on chromosome 5q32 that encodes a member of the collapsin response mediator protein family that forms homotetramers and heterotetramers with CRMP1, DPYSL2, DPYSL4 or DPYSL5, interacting with synaptic vesicle protein 2 and SH3A domain of intersectin. DPYSL3 is necessary for signalling by class-3 semaphorins and subsequent cytoskeletal remodelling; it plays a role in axon guidance, neuronal growth cone collapse and cell migration.
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Alchini et al., "Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton," Journal of Biological Chemistry, vol.