Collapsin response mediator protein 2 | definition of Collapsin response mediator protein 2 by Medical dictionary
DPYSL2 (redirected from Collapsin response mediator protein 2)
DPYSL2 A gene on chromosome 8p22-p21 that encodes a member of the collapsin response mediator protein family, which forms homo- and heterotetramers. DPYSL2 plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration.
DPYSL2 has been implicated in multiple neurological disorders; hyperphosphorylation of the encoded protein may play a role in the development of Alzheimer's disease.
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References in periodicals archive
Khanna, "Specific Binding of Lacosamide to Collapsin Response Mediator Protein 2
(CRMP2) and Direct Impairment of its Canonical Function: Implications for the Therapeutic Potential of Lacosamide," Molecular Neurobiology, vol.
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity.
In addition, ROCK2 can phosphorylate collapsin response mediator protein 2
(CRMP2), another microtubule associated protein, to induce growth cone collapse .