Colestid


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Colestid

 [ko-les´tid]
trademark for a preparation of colestipol, used in treatment of primary hypercholesterolemia.

colestipol hydrochloride

Colestid

Pharmacologic class: Bile acid sequestrant

Therapeutic class: Antihyperlipidemic

Pregnancy risk category NR

Action

Binds bile acids in GI tract and forms insoluble complex, impeding bile acid reabsorption and promoting its excretion. As a result, cholesterol and low-density lipoprotein levels decrease.

Availability

Granules for suspension: 5 g/packet or scoop

Tablets: 1 g

Indications and dosages

Primary hypercholesterolemia

Adults:Granules-5 g P.O. once or twice daily; may increase q 1 to 2 months up to 30 g/day P.O. given in one or two divided doses. Tablets-2 g P.O. once or twice daily; may increase q 1 to 2 months up to 16 g/day P.O. given in one or two divided doses.

Off-label uses

• Digoxin toxicity

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• history of constipation
• breastfeeding patients
• children (safety and efficacy not established).

Administration

• Mix granules with at least 90 ml of liquid, and stir until completely mixed.
• Give tablets with large amount of water.
• Administer other drugs 1 hour before or 4 hours after colestipol.

Adverse reactions

CNS: dizziness, headache, vertigo, anxiety, syncope, fatigue

CV: chest pain

GI: nausea, vomiting, constipation, abdominal discomfort, fecal impaction, flatulence, fatty stools, hemorrhoids, perianal irritation, tongue irritation

Metabolic: deficiency of vitamins A, D, E, and K and folic acid, hyperchloremic acidosis

Musculoskeletal: osteoporosis, backache, muscle and joint pain, arthritis

Skin: irritation, rashes

Interactions

Drug-drug.Amiodarone, corticosteroids, digoxin, diuretics, fat-soluble vitamins (A, D, E, K), folic acid, gemfibrozil, imipramine, methotrexate, mycophenolate, nonsteroidal anti-inflammatory drugs, penicillin G, phosphates, propranolol, tetracyclines, thyroid preparations, ursodiol: decreased absorption of these drugs (when given orally)

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, phosphorus: increased levels

Prothrombin time: prolonged

Patient monitoring

• Monitor lipid levels frequently during first few months of therapy and periodically thereafter.
• Evaluate patient for signs and symptoms of abnormal bleeding.
• Be aware that prolonged use may increase bleeding tendency (from hypoprothrombinemia resulting from vitamin K deficiency). As prescribed and needed, give oral or parenteral vitamin K to reverse this effect.

Patient teaching

• Instruct patient to take granules with 3 to 4 oz of water, fruit juice, soup with high fluid content, cereal, or pulpy fruits (crushed).
• Tell patient to swallow tablets whole, one at a time, and not to crush, cut, or chew them.
• Inform patient that drug may interfere with absorption of many other drugs. Advise him to take other drugs

1 hour before or 4 hours after colestipol.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Colestid

a trademark for an antihyperlipidemic (colestipol hydrochloride).

Colestid

A brand name for COLESTIPOL.
References in periodicals archive ?
Colestid products contain colestipol hydrochloride, which is one of the medications recommended as a first-line treatment after diet for high cholesterol by the National Cholesterol Education Program of the National Heart, Lung and Blood Institute.
Colestid works by traveling through the gastrointestinal tract, attaching itself to certain cholesterol-containing molecules and carrying them out of the body.
The most commonly reported side effect among patients taking Colestid has been constipation, which generally can be minimized or controlled by beginning with a small dose and increasing fluid and fiber intake.
The tablet formulation of Colestid gives patients a convenient alternative to the other granule medications currently on the market that need to be mixed with juice or water.
Colestid may be used alone or in combination with other lipid- lowering drugs.
Colestid Tablets will be available in pharmacies in December.
Upjohn's newest cholesterol-lowering medication, Flavored Colestid Granules, was cleared for marketing by the U.
Colestid is indicated as adjunctive therapy to diet for the reduction of elevated serum total and low-density lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia who do not respond adequately to diet.
The clinical pharmacology section of the package insert for Colestid will state that, "When compared to conventional measures, intensive lipid-lowering combination therapy significantly reduced the frequency of progression and increased the frequency of regression of coronary atherosclerotic lesions in patients with or at risk for coronary artery disease.
Colestid is one of the three medications recommended as first-line treatment after dietary modification for high cholesterol by the National Cholesterol Education Program of the National Heart, Lung, and Blood Institute.
Colestid works by traveling through the gastrointestinal system, attaching itself to certain cholesterol-containing molecules and carrying them out of the body; Colestid is not absorbed by the body(a).
The most commonly reported side effect among Colestid patients has been constipation, which generally can be avoided or controlled by beginning with a small dose and increasing fluid and fiber intake.