Colestid


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Colestid

 [ko-les´tid]
trademark for a preparation of colestipol, used in treatment of primary hypercholesterolemia.

colestipol hydrochloride

Colestid

Pharmacologic class: Bile acid sequestrant

Therapeutic class: Antihyperlipidemic

Pregnancy risk category NR

Action

Binds bile acids in GI tract and forms insoluble complex, impeding bile acid reabsorption and promoting its excretion. As a result, cholesterol and low-density lipoprotein levels decrease.

Availability

Granules for suspension: 5 g/packet or scoop

Tablets: 1 g

Indications and dosages

Primary hypercholesterolemia

Adults: Granules-5 g P.O. once or twice daily; may increase q 1 to 2 months up to 30 g/day P.O. given in one or two divided doses. Tablets-2 g P.O. once or twice daily; may increase q 1 to 2 months up to 16 g/day P.O. given in one or two divided doses.

Off-label uses

• Digoxin toxicity

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• history of constipation

• breastfeeding patients

• children (safety and efficacy not established).

Administration

• Mix granules with at least 90 ml of liquid, and stir until completely mixed.

• Give tablets with large amount of water.

• Administer other drugs 1 hour before or 4 hours after colestipol.

Adverse reactions

CNS: dizziness, headache, vertigo, anxiety, syncope, fatigue

CV: chest pain

GI: nausea, vomiting, constipation, abdominal discomfort, fecal impaction, flatulence, fatty stools, hemorrhoids, perianal irritation, tongue irritation

Metabolic: deficiency of vitamins A, D, E, and K and folic acid, hyperchloremic acidosis

Musculoskeletal: osteoporosis, backache, muscle and joint pain, arthritis

Skin: irritation, rashes

Interactions

Drug-drug. Amiodarone, corticosteroids, digoxin, diuretics, fat-soluble vitamins (A, D, E, K), folic acid, gemfibrozil, imipramine, methotrexate, mycophenolate, nonsteroidal anti-inflammatory drugs, penicillin G, phosphates, propranolol, tetracyclines, thyroid preparations, ursodiol: decreased absorption of these drugs (when given orally)

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, phosphorus: increased levels

Prothrombin time: prolonged

Patient monitoring

• Monitor lipid levels frequently during first few months of therapy and periodically thereafter.

• Evaluate patient for signs and symptoms of abnormal bleeding.

• Be aware that prolonged use may increase bleeding tendency (from hypoprothrombinemia resulting from vitamin K deficiency). As prescribed and needed, give oral or parenteral vitamin K to reverse this effect.

Patient teaching

• Instruct patient to take granules with 3 to 4 oz of water, fruit juice, soup with high fluid content, cereal, or pulpy fruits (crushed).

• Tell patient to swallow tablets whole, one at a time, and not to crush, cut, or chew them.

• Inform patient that drug may interfere with absorption of many other drugs. Advise him to take other drugs

1 hour before or 4 hours after colestipol.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Colestid

A brand name for COLESTIPOL.
References in periodicals archive ?
Most resins appear rectangular or crystalline in shape, but the granule form can occasionally appear round, as depicted in this case of colestipol (Colestid).
Welchol: Daiichi Sankyo Inc, Tokyo, Japan; Colestid: Pfizer Inc, New York, New York; LoCholest: Warner Chilcott Inc, Rockaway, New Jersey; Prevalite: Upsher-Smith Laboratories, Maple Grove, Minnesota; Questran: Par Pharmaceutical, Woodcliff Lake, New Jersey; Kayexalate: Concordia International Corp, Oakville, Ontario, Canada; and Renvela and Renagel: Sanofi SA, Paris, France.
Soon after this, I took him off Lopid and placed him on a combination of the cholesterol-lowering drug colestipol hydrochloride (Colestid) and niacin.
Other resins include the bile sequestrants cholestyramine (Questran, Par Pharmaceutical Inc, Spring Valley, New York), colesevelam (Welchol, Daiichi Sankyo, Parsippany, New Jersey), and colestipol (Colestid, Cholestabyl, Pfizer, New York, New York), used to lower high levels of cholesterol in the blood, especially low-density lipoprotein.
The three main bile acid resins prescribed in the United States are cholestyramine (Questran), colestipol (Colestid) and colesevelam (WelChol).
IMPAX' ANDA for a generic version of Colestid tablets (colestipol hydrochloride tablets), 1 gram, was also approved.
Drug Dosage Cost/Day * atorvastatin 5-80 mg/day $1.16 (5 mg) (Lipitor) fluvastatin 20-80 mg/day $1.48 (40 mg) (Lescol) lovastatin 20-80 mg/day $2.39 (20 mg) pravastatin 10-40 mg/day $2.78 (20 mg) (Pravachol) simvastatin 5-80 mg/day $2.53 (10 mg) (Zocor) NIACIN niacin, extended-release 1-2.5 g/day $1.41 (1 g) (Niaspan) BILE ACID SEQUESTRANTS cholestyramine 4-16 g/day $2.96 (8 g) colesevelam 2.5-3.75 g/day $4.74 (3.75 g) (WelChol) colestipol 5-20 g/day $2.40 (5 g) (Colestid) FIBRATES gemfibrozil 600 mg b.i.d.
The three main bile acid sequestrants currently prescribed in the United States are cholestyramine sucrose (Questran), colestipol (Colestid) and colesevelam (WelChol).
Drug Dosage Cost/Day * atorvastatin 5-80 mg/day $1.16 (5 mg) (Lipitor) fluvastatin 20-80 mg/day $1.48 (Lescol) (40 mg) lovastatin 20-80 mg/day $2.39 (20 mg) pravastatin 10-40 mg/day $2.78 (20 mg) (Pravachol) simvastatin 5-80 mg/day $2.53 (Zocor) (10 mg) NIACIN niacin, extended- 1-2.5 g/day $1.41 (1 g) release (Niaspan) BILE ACID SEQUESTRANTS cholestyramine 4-16 g/day $2.96 (8 g) colesevelam 2.5-3.75 $4.74 (WelChol) g/day (3.75 g) colestipol 5-20 g/day $2.40 (5 g) (Colestid) FIBRATES gemfibrozil 600 mg b.i.d $1.98 fenofibrate 200 mg/day $2.58 (Tricor) Drug Comment ** atorvastatin Most widely prescribed statin, most (Lipitor) potent LDL reducer, and the sole statin not backed by a larger clinical trial demonstrating reductions in acute Ml, mortality, and other key end points.
is seeking O-T-C status for its cholesterol lowering drug Colestid (colestipol HCl), while SmithKline has filed for non-prescription status for the smoking cessation gum Nicorette (nicotine polacrilex).
The three main bile acid resins prescribed in the United States are cholestyramine (Questran, Questran Light, Prevalite, Locholest, Locholest Light), colestipol (Colestid) and colesevelam (WelChol).