Cogan syndrome

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oc·u·lo·ves·tib·u·lo·au·di·to·ry syn·drome

a nonsyphilitic interstitial keratitis characterized by an abrupt onset with vertigo and tinnitus followed by hearing impairment; about 50% of patients have an associated systemic disease, most commonly polyarteritis nodosa.
Synonym(s): Cogan syndrome

Cogan syndrome

An autoimmune condition characterized by interstitial keratitis and bilateral, rapidly progressive audiovestibular dysfunction Clinical Vasculitis of CNS, aorta, heart, pericardium, lungs; ocular complaints–photophobia, blurred vision, lacrimation, pain; Meniere's disease-like Sx–vertigo, ataxia vegetative Sx, with progression to complete absence of vestibular function, manifested by ataxia and oscillopsia, bilateral hearing loss Management High dose steroids, immunosuppression

Cogan syndrome

[David G. Cogan, U.S. ophthalmologist, 1908–1993]
Interstitial keratitis associated with tinnitus, vertigo, and usually deafness.


David G., U.S. ophthalmologist, 1908-1993.
Cogan syndrome - a nonsyphilitic interstitial keratitis with vertigo and tinnitus, followed by deafness. Synonym(s): oculovestibulo-auditory syndrome
Cogan-Reese syndrome - syndrome of glaucoma, iris atrophy, decreased corneal endothelium, anterior peripheral synechia, and multiple iris nodules. Synonym(s): iridocorneal endothelial syndrome
References in periodicals archive ?
Cogan syndrome was initially suspected in view of the characteristic interstitial keratitis, fluctuating sensorineural hearing loss, and episodic vertigo.
When a review of the patient's ophthalmologic examination revealed that he suffered from recurrent iritis and not interstitial keratitis or uveitis, the diagnosis of Cogan syndrome was questioned.
This clinical progress may indicate the existence of an autoimmune disease like Cogan syndrome.