A commonly used clinical estimation of renal function is based upon serum creatinine level as a surrogate marker, applying the Cockcroft-Gault formula
The substudy analysis calculated estimated glomerular filtration rates (eGFR) for patients enrolled in ARISTOTLE by three difference methods: the Cockcroft-Gault formula
, the Chronic Kidney Disease-Epidemiology Collaboration formula, and cystatin C measurement.
Reduced renal function can also be assessed with creatinine-based formulae such as the Cockcroft-Gault formula
(5), which calculates creatinine clearance rate in mL/min, or the Modification of Diet in Renal Disease (MDRD)  formula, which calculates glomerular filtration rate in mL/min/1.
Patients in the Prograf group exhibited higher estimated creatinine clearance rates (eCLcr) using the Cockcroft-Gault formula
and experienced fewer efficacy failures, defined as biopsy proven acute rejection (BPAR), graft loss, death and/or lost to follow-up in comparison to each of the other three groups: Prograf/MMF (20.
The GFR in children older than 12 years can be more accurately estimated from the Cockcroft-Gault formula
used in adults:
These changes translated to a statistically significant increase in creatinine clearance using the Cockcroft-Gault formula
, with infusions of CD-NP at 3, 10 and 20 ng/kg/min resulting in increases of 10% (p=0.
cr]) measured by use of a modified Jaffe method was used to estimate creatinine clearance according to the Cockcroft-Gault formula
Glomerular filtration rate (GFR) was estimated using both the Cockcroft-Gault formula
and the abbreviated Modification of Diet in Renal Disease (MDRD) equation, which is considered by most nephrologists to be more reliable.
A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula
Her GFR as estimated with the widely used Cockcroft-Gault formula
is 45 mL/min per 1.
The African American Study of Kidney Disease and Hypertension (AASK) and the Modification of Diet in Renal Disease (MDRD) trials compared GFR estimation using the new regression equation with three time-honored methods of predicting GFR: 24-hour urine creatinine clearance, the Cockcroft-Gault formula
, and 100/serum creatinine.
A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than the creatinine clearance using the Cockcroft-Gault formula