a test of historical interest: tuberculin, either pure or diluted, is injected intracutaneously into a guinea pig; if the animal is tuberculous, a large papule with a necrotic hemorrhagic center appears in about 24 hours (cocarde or cockade reaction).
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Cockade reactionAn obsolete tuberculin test in which a guinea pig was inoculated subdermally; if reactive, it developed a large, centrally haemorrhagic papule.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.