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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Angel investors of the MUZO Cobblestone Kickstarter campaign are eligible for perks such as early bird discounts on single or multiple quantities of MUZO Cobblestones, MUZO Cobblestones in multiple colors, and a MUZO Cobblestone distributor pack.
Before the stage, Froome had said that the biggest concern about the cobblestones was not riding over them, but the nervousness of the peloton as riders jockey to get up front, which is considered the safest place.
We might complain about the condition of modern road surfaces but compared with such things as cobblestones and so on, they are absolutely excellent - even when riddled with potholes.
Levi Boughton was responsible for first using the cobblestone building method in Paris in 1839.
Those primarily responsible are northern Europeans who have simply picked up a loose cobblestone or piece of mosaic they have found while wandering around Rome.
Often it would take years to collect the number of cobblestones necessary to cover a house.
CAMPAIGNERS have succeeded in preserving some cobblestones in a market.
I know--I was there all three nights on Covent Garden's hard cobblestones.
"What I did was mount a plaque in the sidewalk and put little bronze cobblestones with Adam Smith's head on them so people could unobtrusively find the grave by just following the cobblestones," Lamond says.
Guests picked their way over the cobblestones of New York's Meatpacking District on their way to a party at the Bodum store last week.
Poetry in motion comes to mind as they pulled their heavy load, muscles rippling, hooves striking fire, clattering on the cobblestones as they stamped up the hill.
In brooding, unpopulated streetscapes that show empty West Side intersections, warehouses, or derelict diners and gas stations, Hujar tunes in to the inimitably bilious chiaroscuro of a mercury streetlamp casting its bleaching light on cobblestones, asphalt, corrugated trashcans, and security gates, then abruptly fading out into pools of shadow.