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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
"Breeds with shortened snouts often have thickened keratin layers, a loss of cobblestone appearance, and a dry nose as they are unable to keep their entire nose moisturized and/or exfoliate the keratin normally," says Dr.
The plan would include construction of such roads in 500 villages and 25 cobblestone roads of state importance.
While DelMonte Hotel Group continues to explore growth, Cobblestone Capital will be considering similar partnership opportunities in the future, if they make sense.
Shefchik, vice president of BriMark Builders, which is Cobblestone's in-house construction firm.
Other pieces include The Debonaire Etagere, with cup-and-saucer turned posts and wood framed glass shelves, in Low Tide or in Cobblestone with a Blossom back.
3 report by roads technologist Rick Knap noted that if parking was permitted on the west side of the street between the curve and the intersection with Cobblestone Drive, visibility would be impaired and it would be less safe for drivers exiting the school's driveway and using the intersection.
[USPRwire, Wed Apr 17 2013] Cobblestone Hotels, the fastest growing new build hotel brand in the United States, has selected LRA Worldwide, Inc.
Those primarily responsible are northern Europeans who have simply picked up a loose cobblestone or piece of mosaic they have found while wandering around Rome.
One potential indicator species of natural habitat in New York State is the cobblestone tiger beetle (Cicindela marginipennis Dejean), a rare species adapted to natural river disturbances that maintain its required habitat, cobble bars.
Josephson was previously managing director and principal of JBK Capital and Cobblestone Advisory Group, where he was directly responsible for the modification of over $300 million of senior securitized and mezzanine debt for various borrowers.
In a striking coincidence, Supervisor Vandenbergh had just built a cobblestone house that matched the committee's description.
I first heard about the fabulous footwear of San Miguel Shoe in the tiny village of Ajijic, near in central Mexico, A well-dressed, well-traveled Canadian woman assured me that the sandal with three-inch-wide elastic straps is the most comfortable shoe for maneuvering Mexico's treacherous cobblestone streets, and suggested I visit the factory store ( when J reached San Miguel de Allende.