coagulopathy

(redirected from Coagulation disturbance)
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Related to Coagulation disturbance: Coagulation defects

coagulopathy

 [ko-ag″u-lop´ah-the]
any disorder of blood coagulation.
consumption coagulopathy disseminated intravascular coagulation.

co·ag·u·lop·a·thy

(kō'ag-yū-lop'ă-thē),
A disease affecting the coagulability of the blood.

coagulopathy

/co·ag·u·lop·a·thy/ (ko-ag″u-lop´ah-the) any disorder of blood coagulation.
consumption coagulopathy  disseminated intravascular coagulation.

coagulopathy

[kō·ag′yəlop′əthē]
a pathologicalondition that reduces the ability of the blood to coagulate, resulting in uncontrolled bleeding.

coagulopathy

Hematology A clotting defect in which bleeding does not stop in the usual time period Etiology Hemophilia, drug-induced defects–eg, aspirin, thrombocytopenia, liver disease, Von Willebrand's disease. See Consumption coagulopathy, DIC, Leukemic coagulopathy.

co·ag·u·lop·a·thy

(kō-ag'yū-lop'ă-thē)
A disease affecting the coagulability of the blood.

Coagulopathy

A disorder in which blood is either too slow or too quick to coagulate (clot).
Mentioned in: Cerebral Palsy

coagulopathy

any disorder of blood coagulation. See also hemophilia.

consumption coagulopathy
a bleeding tendency due to a reduction in clotting factors caused by their utilization. See also disseminated intravascular coagulation.
disseminated intravascular coagulopathy (DIC)
see disseminated intravascular coagulation.
hepatic coagulopathy
impaired synthesis of most clotting factors, including factors I, II, V, VII, IX and X, as well as other substances involved in the fibrinolytic system, in severe liver disease can cause significant abnormalities in coagulation.
References in periodicals archive ?
Even considering these shortfalls, there is a growing body of evidence indicating that in order to improve survival in the seriously injured we need to address the possibility of a coagulation disturbance much earlier than was previously thought.
Metabolic acidosis has been incriminated as one of the instigators of coagulation disturbances following injury.
13,14] Given the incidence of hyperchloraemia in our patient population, which in addition to hypoperfusion may contribute to metabolic acidosis, acute kidney injury and coagulopathy, the BD may be a more useful predictor of the risk of coagulation disturbances and an indicator for the early use of plasma rather than clear fluids for resuscitation.
Tissue factor exposure has been incriminated as a major trigger mechanism, [2,15] and it may be assumed that a higher ISS would be associated with more severe tissue damage, an increase in coagulation disturbances and a higher mortality rate.
After the diagnosis was achieved, the second issue raised by our patients was the need to rapidly treat their coagulation disturbance as they both required emergent surgical intervention for surgical decompression of the hematoma and removal of a bone flap for the treatment of increased ICP in our first patient and for ventriculostomy placement to treat obstructive hydrocephalus in the second case.
Following its efficacy in the hemophilia population, there has been an increasing body of clinical experience with rFVIIa in the nonhemophiliac population with coagulation disturbances and bleeding of various etiologies.
Preliminary experience with the use of recombinant factor VIIa to treat coagulation disturbances in pediatric patients.
Table 1 Etiology of the coagulation disturbance in patients receiving recombinant factor VIIa No.
Conclusion: Recombinant factor VIIa can be used to effectively reverse coagulation disturbances in the pediatric patient even when treatment with fresh frozen plasma has failed.
Various etiologic factors may be responsible for coagulation disturbances in children, including congenital deficiencies; hepatic insufficiency; disseminated intravascular coagulation (DIC) from sepsis, shock, or closed head injury; dilution of coagulation factors after cardiopulmonary bypass or large-volume transfusions; and medications.
In addition, in selected cases, despite the administration of significant volumes of FFP, coagulation disturbances may persist.
This problem of paradoxical embolism is of great concern in patients with patent foramen ovale who take oral contraceptives, smoke cigarettes, have a history of venous thromboembolism, have certain coagulation disturbances or who are pregnant.