Coagulation cascade


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Related to Coagulation cascade: Coagulation factors

cascade

 [kas-kād´]
a series of steps or stages (as of a physiological process) that, once initiated, continues to the final step because each step is triggered by the preceding one, resulting in amplification of the signal, information, or effect at each stage. In electronics, the term is applied to multiple amplifiers. Examples in biochemistry include blood coagulation and the complement system.
coagulation cascade the series of steps beginning with activation of the intrinsic or extrinsic pathways of coagulation, or of one of the related alternative pathways, and proceeding through the common pathway of coagulation to the formation of the fibrin clot.
The coagulation cascade. This scheme emphasizes the understanding of 1, the importance of the tissue factor pathway in initiating clotting in vivo; 2, the interactions between pathways; and 3, the pivotal role of thrombin in sustaining the cascade by feedback activation of coagulation factors. HMWK = high-molecular-weight kininogen; PK = prekallikrein; PL = phospholipid; PT = prothrombin; TF = tissue factor; Th = thrombin. From Schafer, 1994.

Coagulation cascade

The sequence of biochemical activities, involving clotting factors, that stop bleeding by forming a clot.
References in periodicals archive ?
That is, they prevent aggregation of red blood cells, which as you may recall, is part of the coagulation cascade. (39,40) An image I find effective in describing fish oils to my patients is that they act like Teflon to prevent this aggregating effect.
Platelet activation promotes platelet aggregation and stimulates the coagulation cascade. The coagulation cascade is an illustrative model for the initiation and sequential activation of serine protease coagulation factors which culminates in the formation of thrombin (coagulation factor IIa).
Rethinking the coagulation cascade. Current Haematology Reports 2005; 4: 391-6.
It has been suggested that inhibition of more proximal stages of the coagulation cascade might be more effective in inhibiting atherothrombosis.
The D-dimer antigen is a product of fibrin degradation that is formed by the sequential action of enzymes of coagulation cascade.2
Platelet dysfunction and abnormalities in coagulation cascade can accelerate atherogenesis in diabetic patients.
It provides information on clot initiation, clot growth, final clot strength, and presence of fibrinolytic clot breakdown, giving a global evaluation of all phases of the coagulation cascade (Schochl et al., 2011).
Available literature on the topic identifies the contact between blood and the dialyzer as the primary trigger for the coagulation cascade during hemodialysis (Frank et al., 2001; Kourtzelis et al., 2010).
Acute inflammatory events, such as those that occur in ALI, lead to dysregulation of the coagulation cascade. Indeed, ALI is characterised by profound alterations in both systemic and intra-alveolar coagulation and fibrinolysis [9].
They tend to provide data on isolated aspects of coagulation cascade and overlook factors such as rate of clot formation, time taken for maximal clot retraction, and maximal clot strength.
These phospholipids are exposed on the outer membrane of MP and are considered to be the main initiators of the coagulation cascade [28].
Their pharmacologic targets in the coagulation cascade are described in Figure 1, and their general pharmacologic characteristics are summarized in Table 2.