That is, they prevent aggregation of red blood cells, which as you may recall, is part of the coagulation cascade
. (39,40) An image I find effective in describing fish oils to my patients is that they act like Teflon to prevent this aggregating effect.
Platelet activation promotes platelet aggregation and stimulates the coagulation cascade
. The coagulation cascade
is an illustrative model for the initiation and sequential activation of serine protease coagulation factors which culminates in the formation of thrombin (coagulation factor IIa).
Rethinking the coagulation cascade
. Current Haematology Reports 2005; 4: 391-6.
It has been suggested that inhibition of more proximal stages of the coagulation cascade
might be more effective in inhibiting atherothrombosis.
The D-dimer antigen is a product of fibrin degradation that is formed by the sequential action of enzymes of coagulation cascade
Platelet dysfunction and abnormalities in coagulation cascade
can accelerate atherogenesis in diabetic patients.
It provides information on clot initiation, clot growth, final clot strength, and presence of fibrinolytic clot breakdown, giving a global evaluation of all phases of the coagulation cascade
(Schochl et al., 2011).
Available literature on the topic identifies the contact between blood and the dialyzer as the primary trigger for the coagulation cascade
during hemodialysis (Frank et al., 2001; Kourtzelis et al., 2010).
Acute inflammatory events, such as those that occur in ALI, lead to dysregulation of the coagulation cascade
. Indeed, ALI is characterised by profound alterations in both systemic and intra-alveolar coagulation and fibrinolysis .
They tend to provide data on isolated aspects of coagulation cascade
and overlook factors such as rate of clot formation, time taken for maximal clot retraction, and maximal clot strength.
These phospholipids are exposed on the outer membrane of MP and are considered to be the main initiators of the coagulation cascade
Their pharmacologic targets in the coagulation cascade
are described in Figure 1, and their general pharmacologic characteristics are summarized in Table 2.