mice develop moderate lupus-like disease, (22) CD72 appears to be a major inhibitory co-receptor
that activates SHP-1 to prevent autoimmunity.
GBR 1342 simultaneously targets CD38, as well as the CD3 T cell co-receptor
Identification of a major co-receptor
for primary isolates of HIV-1.
The new study builds on previous discoveries by the Farzan laboratory, which show that a co-receptor
called CCR5 contains unusual modifications in its critical HIV-binding region, and that proteins based on this region can be used to prevent infection.
cell surface protein and a chemokine co-receptor
present on the host cell.
INTRODUCTION: HIV most commonly uses CCR5 as a co-receptor
to enter its target cells.
JAM proteins serve as a sort of co-receptor
for Notch signaling in that they are required to maintain close contact between signal-emitting and signal-receiving cells to permit strong activation of Notch in the precursors of HSCs.
expressed by T cells is Cytotoxic T Lymphocyte Antigen-4 (CTLA-4), which interacts with the same ligand on the APC.
Although the HIV virus was initially discovered to infect cells via a receptor called CD4, researchers found in 1996 that HIV infection requires a co-receptor
, usually CCR5.
It is well established that CCR5 is an essential co-receptor
required for HIV infection," said Dr.
What's more, blocking the receptor with the CCR5 antagonists Maraviroc and Vicriviroc, two drugs that slow down the spread of the HIV virus by targeting the CCR5 co-receptor
of the chemokine CCL5, also prevents migration and spread of breast cancer cells, the researchers found.
Since certain antirctroviral drugs act by blocking HIV entry through co-receptor
activation, additional resistance tests are necessary to determine the efficacy of those drugs.