A standard TAC consists of an antigen-binding domain, T cell receptor recruiting domain, and co-receptor
domain, in which each domain can be designed by Creative Biolabs to utilize a variety of proteins, allowing the T cell antigen coupler to be modified for a more efficient response to a large number of different antigens.
David Briscoe, Professor of Pediatrics at Harvard Medical School, as strategic advisor to consult on the ongoing development of therapeutics based on the NRP2 co-receptor
and related signaling pathways.
This next-generation SPEAR T-cell, known as ADP-A2M4CD8, expresses the CD8alpha co-receptor
alongside the engineered TCR that targets MAGE-A4.
The product is based on the company's proprietary BEAT platform and simultaneously targets CD38, an antigen known to be implicated in haematological malignancies as well as some solid tumours, and the CD3 T cell co-receptor
(2-5) The Wnt signaling pathway is initiated by binding the Wnt family proteins to a cell-surface receptor, Frizzled, and a co-receptor
, low-density lipoprotein receptor-related protein 5/6 (LRP5/6).
HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor
on target T cells.
Identification of a major co-receptor
for primary isolates of HIV-1.
The new study builds on previous discoveries by the Farzan laboratory, which show that a co-receptor
called CCR5 contains unusual modifications in its critical HIV-binding region, and that proteins based on this region can be used to prevent infection.
The initial step in membrane fusion begins with binding of the viral envelope protein (Env, consisting of a trimer of gp120-gp41 heterodimers) to the [CD4.sup.+] cell surface protein and a chemokine co-receptor
present on the host cell.
The thymus plays a pivotal role in the adaptive immune system and the CD3 complex is a co-receptor
that serves as a marker for general T cell identification in fish (0vergard et al., 2009).
ErbB2 binds no ligand, but upon stimulation acts as a co-receptor
for another ErbB family member (1).
INTRODUCTION: HIV most commonly uses CCR5 as a co-receptor
to enter its target cells.