coreceptor

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co·re·cep·tor

(kō'rē-sep'tōr),
A cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions.

co·re·cep·tor

(kō'rĕ-sep'tŏr)
A cell surface protein that increases the sensitivity of the antigen receptor to antigen by binding to other ligands.

coreceptor

(ko?re-sep'tor) [ com- + receptor]
A structure on a cell membrane that enhances the action of the cell receptor.

CCR5 coreceptor

A cell surface receptor found on macrophages that facilitates entry of HIV-1 into these cells. Chemokines released by T cells attempt to compete with HIV by blocking the receptor to prevent infection.

CXCR4 coreceptor

A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells.
Synonym: fusin
References in periodicals archive ?
A standard TAC consists of an antigen-binding domain, T cell receptor recruiting domain, and co-receptor domain, in which each domain can be designed by Creative Biolabs to utilize a variety of proteins, allowing the T cell antigen coupler to be modified for a more efficient response to a large number of different antigens.
David Briscoe, Professor of Pediatrics at Harvard Medical School, as strategic advisor to consult on the ongoing development of therapeutics based on the NRP2 co-receptor and related signaling pathways.
This next-generation SPEAR T-cell, known as ADP-A2M4CD8, expresses the CD8alpha co-receptor alongside the engineered TCR that targets MAGE-A4.
The product is based on the company's proprietary BEAT platform and simultaneously targets CD38, an antigen known to be implicated in haematological malignancies as well as some solid tumours, and the CD3 T cell co-receptor.
(2-5) The Wnt signaling pathway is initiated by binding the Wnt family proteins to a cell-surface receptor, Frizzled, and a co-receptor, low-density lipoprotein receptor-related protein 5/6 (LRP5/6).
The new study builds on previous discoveries by the Farzan laboratory, which show that a co-receptor called CCR5 contains unusual modifications in its critical HIV-binding region, and that proteins based on this region can be used to prevent infection.
The initial step in membrane fusion begins with binding of the viral envelope protein (Env, consisting of a trimer of gp120-gp41 heterodimers) to the [CD4.sup.+] cell surface protein and a chemokine co-receptor present on the host cell.
The thymus plays a pivotal role in the adaptive immune system and the CD3 complex is a co-receptor that serves as a marker for general T cell identification in fish (0vergard et al., 2009).
ErbB2 binds no ligand, but upon stimulation acts as a co-receptor for another ErbB family member (1).
INTRODUCTION: HIV most commonly uses CCR5 as a co-receptor to enter its target cells.