The traditional Chinese medicine osthole (7-methoxy-8(3-methyl-2-butenyl)- coumarin) is a naturally occurring coumarin derivative, which can be derived from Cnidium monnieri
(L.) Cusson, Angelica archangelica L., and imperatorin .
Xu et al., "Osthole, a coumadin analog from Cnidium monnieri
(L.) Cusson, ameliorates nucleus pulposus-induced radicular inflammatory pain by inhibiting the activation of extracellular signal-regulated kinase in rats," Pharmacology, vol.
Osthole, a coumarin derivative isolated from the fruit of Cnidium monnieri
(L.) Cusson, has been widely used for the treatment of skin diseases and gynecopathy.
Osthole is a coumarin compound found in several medicinal plants such as Cnidium monnieri
and Angelica pubescens .
Also the furocoumarin has been reported in various medicinal plants, such as Cnidium monnieri
(Sun et al., 1990; Chiou et al., 2001), Heracleum rapula (Liu et al., 2006), Angelica spp.
The linear furanocoumarin imperatorin and the coumarin osthole extracted from Cnidium monnieri
(L.) Cusson fruit were effective against larvae of Culex pipiens pallens Coquillett and Ae.
Some of these herbs are Herba Epimedii , Cnidium monnieri
(L.) Cussion, Rhizoma Drynariae, and Psoralea corylifolia.
INCI name: angelic sinensis (and) cnidium monnieri
(and) coptis chinesis (and) dictamnus dasycarpus (and) evodia rutaecarpa (and) phellodendron chinensis (and) scutellaria haicalensis (and) sophora fiavescens
Antimutagenicity assays of water extract from the fruits of Cnidium monnieri
Our previous studies found that osthol, an active constituent isolated from Cnidium monnieri
(L.) Cusson (Apiaceae), could ameliorate the accumulation of lipids and decrease the lipid levels in serum and hepatic tissue in alcohol-induced fatty liver mice and rats.
A variety of botanicals such as Tribulus terrestris, Aframomum melegueta, Eurycoma longifolia, Cnidium monnieri
, Ferula harmonis, Mucuna pruriens, Lepidium meyenii and yohimbine as an alkaloid obtained from the bark of Pausinystalia johimbe (Corynanthe yohimbe) (Tharakan and Manyam, 2005), as well as Passiflora incarnate (Dhawan et al., 2003) are reported to have a potential effect on the sexual functions, supporting older claims and offering new hope (Tharakan and Manyam, 2005).
Determination of coumarins in Cnidium monnieri
fructus by high-performance liquid chromatography.