Clostridium histolyticum


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Clos·trid·i·um his·to·ly't·i·cum

a bacterial species found in war wounds, where it induces necrosis of tissue; it produces cytolytic exotoxins that cause local necrosis and sloughing on injection; it is not toxic on feeding; it is pathogenic for small laboratory animals.

Clos·trid·i·um his·to·lyti·cum

(klos-trid'ē-ŭm his-tō-lit'i-kŭm)
A bacterial species found in war wounds, where it induces necrosis of tissue; it produces a cytolytic exotoxin that causes local necrosis and sloughing on injection; it is not toxic on feeding; it is pathogenic for small laboratory animals.

Clostridium histolyticum

A species found in cases of gas gangrene.
See also: Clostridium

Clostridium

a genus of anaerobic spore-forming bacteria of the family Bacillaceae. Most are gram-positive rods.

Clostridium bifermentans, Clostridium sordelli
see malignant edema.
Clostridium botulinum
causes botulism from neurotoxin produced during vegetative growth. C. botulinum types B, C and D are associated with disease in animals but the type prevalence varies geographically. See botulism.
Clostridium butyricum
involved in the spoilage of meat.
Clostridium cadaveris
may be associated with colitis X in horses.
Clostridium chauvoei
formerly called C. feseri. See blackleg.
Clostridium colinum
cause of ulcerative enteritis and liver necrosis in quail, turkeys, grouse, partridge and chickens. Not an accredited species.
Clostridium difficile
see antibiotic-associated colitis.
Clostridium feseri
now called C. chauvoei (above).
Clostridium haemolyticum
formerly called C. novyi type D. See bacillary hemoglobinuria.
Clostridium histolyticum
a species found in feces, soil and sometimes wound infections. An important cause of meat spoilage.
Clostridium nigrificans
a thermophilic spoiler of canned meat producing hydrogen sulfide gas and causing purple staining of the inside of the can. Now called Desulfotomaculum nigrificans.
Clostridium novyi
see infectious necrotic hepatitis. See also C. haemolyticum (above). Previously called C. oedematiens. Type A causes malignant edema in cattle and sheep, and big head in rams, type B causes infectious necrotic hepatitis (black disease), and type C has been associated with osteomyelitis in buffalo.
Clostridium overgrowth
see bacterial overgrowth.
Clostridium parabotulinum
a proteolytic subgroup of C. botulinum; not a valid species.
Clostridium perfringens
cause of enterotoxemia. Type A causes malignant edema, type B causes dysentery in lambs and enterotoxemia, type C causes struck in sheep and necrotic enteritis in piglets, type D causes enterotoxemia and type E causes necrotic enteritis. Previously called C. welchii.
Clostridium putrefaciens
causes deep bone taint in hams. See also C. putrificum (below).
Clostridium putrificum
a cause of bone taint in cured hams. There is no detectable abnormality on the surface of the ham.
Clostridium septicum
formerly called C. septique. See malignant edema, braxy.
Clostridium sordelli
cause of a small proportion of cases of gas gangrene in ruminants. See also abomasitis.
Clostridium spiroforme
associated with enteritis and enterocolitis in rabbits, guinea pigs and foals.
Clostridium sporogenes
an apathogenic clostridium often found in lesions of gas gangrene.
Clostridium tetani
a common inhabitant of soil and human and horse intestines, and the cause of tetanus in humans and domestic animals.
Clostridium villosum
found in fight abscesses and pleurisy in cats.
Clostridium welchii
see C. perfringens (above).
References in periodicals archive ?
Collagenase clostridium histolyticum is a proteinase that hydrolyzes collagen, resulting in destruction of collagen deposits.
Trial patients receiving collagenase clostridium histolyticum indicated statistically significant levels of improvement in the appearance of cellulite with treatment, as measured by the trial's primary endpoint (p
The EU approval of collagenase clostridium histolyticum is based on results from two pivotal studies, Collagenase Option for Reduction of Dupuytren's (CORD I and CORD II).
A variety of other medications have been used for intralesional injection, including verapamil, nicardipine, interferon alpha-2b, and more recently, collagenase clostridium histolyticum (CCH) (Jordan et al.
b) Probiotic supplementation was associated with reduced excessive crying, increased stool frequency and reduced Clostridium histolyticum colonisation;
The formulation, made up of two collagenases naturally produced by the bacterium Clostridium histolyticum, is injected into the cord at 4-week intervals, for a maximum of three injections), according to the manufacturer, Auxilium Pharmaceuticals Inc.
XIAFLEX is a biologic approved in the US, EU, Canada and Australia for the treatment of adult DC patients with a palpable cord, the company said adding that it consists of a combination of two subtypes of collagenase, derived from Clostridium histolyticum.
In addition, XIAFLEX consists of a combination of two subtypes of collagenase, derived from Clostridium histolyticum.
Biopharmaceutical company Auxilium Pharmaceuticals Inc (NasdaqGS:AUXL) revealed on Friday that it has dosed the first patient in its Phase 2b study of collagenase clostridium histolyticum (CCH) for the treatment of adult patients with adhesive capsulitis, commonly known as frozen shoulder syndrome (FSS).
M2 PHARMA-December 16, 2013-Auxilium Pharmaceuticals Inc doses first patient in Phase 2b study of collagenase clostridium histolyticum for treating frozen shoulder syndrome
Speciality biopharmaceutical company Auxilium Pharmaceuticals Inc (Nasdaq:AUXL) announced on Thursday that the US Food and Drug Administration (FDA) has accepted for filing and granted standard review status to its supplemental Biologics License Application (sBLA) for XIAFLEX (collagenase clostridium histolyticum or CCH), a novel, in-office biologic therapy for the potential treatment of Peyronie's disease (PD).
Canadian approval was awarded to Auxilium for XIAFLEX (collagenase clostridium histolyticum or CCH), a novel, first-in-class biologic for the treatment of Dupuytren's contracture in adults with a palpable cord in Canada.

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