Clostridium difficile colitis


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Clostridium difficile colitis

Infectious disease Colonic infection by C difficile Clinical Some are asymptomic and become C difficile carriers; more commonly, diarrhea, abdominal pain, colitis, fever, vomiting dehydration; if severe, pseudomembranous colitis, with possible perforation Diagnosis Stool—cytotoxicity assay is sensitive–≥ 94% and specific–≥ 99%, but expensive; ELISAs are more cost-effective but less sensitive Lab ↑ WBC Treatment Metronidazole–98% response rate, vancomycin–96%, bacitracin–83%, cholestyramine–68%. See Pseudomembranous colitis.
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Jones, "A report of fecal transplantation for refractory clostridium difficile colitis in an orthotopic liver transplant recipient," Journal of Gastroenterology and Hepatology Research, vol.
Kefalas, "Acute Appendicitis in the Setting of Clostridium difficile Colitis: Case Report and Review of the Literature," Clinical Gastroenterology and Hepatology, vol.
Logan et al., "Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole," Clinical Infectious Diseases, vol.
Pamer, "Critical role for myd88-mediated neutrophil recruitment during Clostridium difficile colitis," Infection and Immunity, vol.
Lamont, "Clostridium difficile colitis," The New England Journal of Medicine, vol.
Clostridium difficile colitis in patients after kidney and pancreas-kidney transplantation.
(7.) Brown TA, Rajappannar L, Dalton A, et al: Acute Appendicitis in the Setting of Clostridium difficile Colitis: Case Report and Review of the Literature.
CASE FACTS: Pamela Winter was admitted to JFK Medical Center on October 30, 2005, while suffering from clostridium difficile colitis. Alter admission, Pamela developed hospital-acquired pneumonia, an infection in her blood stream that may have been the product of a perforated intestine, and anemia.
similar geographic variations of mortality and hospitalization associated with IBD and Clostridium difficile colitis. Inflamm Bowel Dis.
Clostridium difficile colitis: an increasing hospital-acquired illness.

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