Clostridium difficile


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Related to Clostridium difficile: Clostridium difficile colitis

Clos·trid·i·um dif·fi·cile

Avoid the mispronunciation dĭf-ĭ-sēl' of this Latin word, which is correctly pronounced dĭ-fĭs'ĭ-lē.
a bacterial species found in feces of humans and animals. It colonizes newborn infants, who are spared from toxin-induced diarrheal disease. Pathogenic for human beings, guinea pigs, and rabbits; frequent cause of colitis and diarrhea following antibiotic use. Found to be a cause of pseudomembranous colitis and associated with a number of intestinal diseases that are linked to antibiotic therapy; also the chief cause of nosocomial diarrhea.
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Clostridium difficile

(dĭf′ĭ-sēl′, dĭf′ĭ-sēl′, dĭf′ĭ-kē′lā)
n.
A bacterium that causes an infectious form of severe diarrhea especially in elderly people on antibiotic therapy and in hospitalized patients. Also called C. diff..

Clostridium difficile

A common cause of bacterial colitis; it is the causative agent in 99% of pseudomembranous colitis, and 20-30% of antibiotic-associated diarrhea

Clos·trid·i·um dif·fi·ci·le

(klos-trid'ē-ŭm di-fis'i-lē)
Gram-positive obligate anaerobic or microaerophilic, rod-shaped bacterium; causes sometimes severe antibiotic-associated colitis.
Synonym(s): C-Diff, CDT.
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Clostridium difficile

A fecal organism endemic in hospitals and responsible for the majority of hospital-acquired cases of diarrhoea in elderly patients. Its prevalence in hospital is largely due to the high levels of antibiotic usage. Bowel infection can be cleared by oral treatment with the antibiotic vancomycin which is not appreciably absorbed into the bloodstream. Up to 40 percent of hospitalized patients are colonized with this organism. Only about 3 percent of healthy adults carry it. A previously uncommon strain with variations in toxin genes has emerged as a cause of C. difficile -associated disease.
References in periodicals archive ?
Burden of Clostridium difficile infection in the United States.
Clinical significance of direct cytotoxicity and toxigenic culture in Clostridium difficile infection.
Evaluation of diagnostic tests for Clostridium difficile infection.
Development of a consensus method for culture of Clostridium difficile from meat and its use in a survey of U.S.
It is not that trehalose increases the number of the bacteria, but it does stimulate a higher production of a Clostridium difficile toxin which is the cause of the life-threatening illness.
Collignon, "Clostridium difficile carriage in healthy infants in the community: A potential reservoir for pathogenic strains," Clinical Infectious Diseases, vol.
Berger, "Clostridium difficile infection following chemotherapy," Recent Patents on Anti-Infective Drug Discovery, vol.
Johnson et al., "Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)," Infection Control & Hospital Epidemiology, vol.
"We are loading the hospital with Clostridium difficile, and the hospital environment is also loaded with Clostridium difficile so we are bringing it into the community.

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