anergy

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anergy

 [an´er-je]
1. lack of energy; extreme passivity.
2. diminished reactivity to specific antigen(s). adj., adj aner´gic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

an·er·gy

(an'er-jē),
1. In a person, absence of the ability to generate a sensitivity reaction to substances expected to be antigenic (immunogenic, allergenic).
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]
Farlex Partner Medical Dictionary © Farlex 2012

anergy

Depression or absence of an immune response to an antigen to which a host was previously sensitive. Anergy is characterised by decreased or absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity (e.g., to PPD, Candida antigens or DCNB).

Anergy can be induced in mature and differentiated CD4+ T cells by exposure to complexes of antigen and appropriate (self) MHC in absence of certain uncharacterised co-stimulatory signals on the antigen-presenting cells. In patients who have received blood transfusions, anergy may be induced by presentation of antigen by “nonprofessional” antigen-presenting cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

anergy

Immunology Depression or absence of an immune response to an antigen to which the host was previously sensitive; it is characterized by ↓/absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity–eg, to PPD, Candida antigens, or DCNB. See Clonal anergy, Deletion. Cf Allergy.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

an·er·gy

(an'ĕr-jē)
1. Absence of ability to generate a sensitivity reaction in a subject to substances expected to be antigenic (immunogenic, allergenic) in that individual.
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

anergy

Specific immunological tolerance in which T cells and B cells fail to respond normally by producing an immune response to antigens. The state can be reversed.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

anergy

loss or weakening of the immune response to an irritating agent or ANTIGEN. A T-CELL that encounters an antigen and does not respond to it is anergic. Contrasts with ALLERGY where there is an overreaction, rather than lack of reaction, to a substance.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

an·er·gy

(an'ĕr-jē)
1. In a person, absence of the ability to generate a sensitivity reaction to substances expected to be antigenic (immunogenic, allergenic).
2. Lack of energy.
[G. an- priv. + energeia, energy, from ergon, work]
Medical Dictionary for the Dental Professions © Farlex 2012