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clomiphene citrate (clomifene (UK))

Clomid, Serophene

Pharmacologic class: Chlorotrianisene derivative

Therapeutic class: Fertility drug, ovulation stimulant

Pregnancy risk category X


Binds with estrogen receptors in cytoplasm, increasing secretion of folliclestimulating hormone, luteinizing hormone, and gonadotropin in hypothalamus and pituitary gland. These actions induce ovulation.


Tablets: 50 mg

Indications and dosages

Ovarian failure

Adults: 50 mg/day P.O. for 5 days starting any time in patients with no recent uterine bleeding; or 50 mg/day P.O. starting on fifth day of menstrual cycle. If ovulation doesn't occur, increase to 100 mg/day P.O. for 5 days. Start next course of therapy as early as 30 days after previous course. If patient doesn't respond after three courses, no further doses are recommended.

Off-label uses

• Male sterility (controversial)


• Hepatic disease
• Organic intracranial lesions
• Uncontrolled thyroid or adrenal dysfunction
• Ovarian cyst
• Abnormal uterine bleeding or bleeding of undetermined origin
• Pregnancy




• Obtain pregnancy test before therapy begins.
• Be aware that patient should undergo pelvic and eye examinations before starting therapy.

Adverse reactions

CNS: nervousness, insomnia, dizziness, light-headedness

CV: vasomotor flushing

EENT: visual disturbances

GI: nausea; vomiting; abdominal discomfort, distention, and bloating

GU: breast tenderness, ovarian enlargement, multiple pregnancies, birth defects in resulting pregnancies, ovarian hyperstimulation syndrome, uterine bleeding


None significant

Patient monitoring

• Monitor patient for bleeding and other adverse reactions.

Patient teaching

Instruct patient to immediately report signs and symptoms of ovarian hyperstimulation syndrome, including nausea, vomiting, diarrhea, abdominal or pelvic pain, and swelling in hands or legs.
• Tell patient to report bleeding.
• Advise patient not to take drug if she is or may become pregnant.
• Inform patient that drug increases risk of multiple births, which heightens maternal risk.
• As appropriate, review all other significant and life-threatening adverse reactions.


A trademark for the drug clomiphene.


a trademark for a nonsteroidal fertility drug (clomiPHENE citrate).


A brand name for CLOMIPHENE (clomifene).
References in periodicals archive ?
Clomid has a high rate of success among women without significant fertility problems and many get pregnant within two or three cycles of taking it.
Clomid is FDA approved for women only, not for men.
Q MY boyfriend and I have been trying for a baby and the specialist has put me on Clomid.
Fenton refused to authorize a refill of her prescription for the fertility drug Clomid on the same grounds.
Experts put Anna on fertility drug Clomid - and warned there was a SMALL chance of a multiple birth.
The couple decided that they wanted a brother or sister for Rhys and undertook a procedure called Clomid, which corrects problems with ovulation.
There are also growing calls for tighter control of controversial drug Clomid, which is unlicensed by the Human Fertilisation and Embryology Authority (HFEA) and has been blamed for boosting the number of multiple births.
Julia has already begun a series of fertility shots with the drug Clomid," says a source close to her.
Fertility enhancing drugs; for example, clomid increases female ovulation
The 'this' in question was the 'good old-fashioned' drug Clomid - and it worked.
Guay has authored numerous publications on the use of Clomid in the treatment of secondary hypogonadism), Dr.