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clomiphene citrate (clomifene (UK))

Clomid, Serophene

Pharmacologic class: Chlorotrianisene derivative

Therapeutic class: Fertility drug, ovulation stimulant

Pregnancy risk category X


Binds with estrogen receptors in cytoplasm, increasing secretion of folliclestimulating hormone, luteinizing hormone, and gonadotropin in hypothalamus and pituitary gland. These actions induce ovulation.


Tablets: 50 mg

Indications and dosages

Ovarian failure

Adults: 50 mg/day P.O. for 5 days starting any time in patients with no recent uterine bleeding; or 50 mg/day P.O. starting on fifth day of menstrual cycle. If ovulation doesn't occur, increase to 100 mg/day P.O. for 5 days. Start next course of therapy as early as 30 days after previous course. If patient doesn't respond after three courses, no further doses are recommended.

Off-label uses

• Male sterility (controversial)


• Hepatic disease

• Organic intracranial lesions

• Uncontrolled thyroid or adrenal dysfunction

• Ovarian cyst

• Abnormal uterine bleeding or bleeding of undetermined origin

• Pregnancy




• Obtain pregnancy test before therapy begins.

• Be aware that patient should undergo pelvic and eye examinations before starting therapy.

Adverse reactions

CNS: nervousness, insomnia, dizziness, light-headedness

CV: vasomotor flushing

EENT: visual disturbances

GI: nausea; vomiting; abdominal discomfort, distention, and bloating

GU: breast tenderness, ovarian enlargement, multiple pregnancies, birth defects in resulting pregnancies, ovarian hyperstimulation syndrome, uterine bleeding


None significant

Patient monitoring

• Monitor patient for bleeding and other adverse reactions.

Patient teaching

Instruct patient to immediately report signs and symptoms of ovarian hyperstimulation syndrome, including nausea, vomiting, diarrhea, abdominal or pelvic pain, and swelling in hands or legs.

• Tell patient to report bleeding.

• Advise patient not to take drug if she is or may become pregnant.

• Inform patient that drug increases risk of multiple births, which heightens maternal risk.

• As appropriate, review all other significant and life-threatening adverse reactions.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug clomiphene.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A brand name for CLOMIPHENE (clomifene).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
For those with secondary testosterone deficiency coming from the hypothalamus-pituitary axis, which is usually the case for younger men (<50 years), HCG and Clomid MAY be superior to TRT.
Clomiphene (Clomid, Serophene) is used to induce ovulation (sometimes called controlled ovarian hyperstimulation).
Mrs Lamb had taken Clomid, which stimulates ovulation, before falling pregnant with the sextuplets.
(6.) Clomid official FDA information, side effects and use.
a flexible range of funds to help pay for fertility treatment options like Clomid, PCOS treatment, IVF, IUI, ICSI, surgery, tubal ligation reversals, and donor eggs." (80)
Agents used were clomiphene (Clomid), clomiphene/human menopausal gonadotrophin, and follicle-stimulating hormone/human menopausal gonadotrophin.
Tabela 1: Medicamentos mencionados pelos voluntarios no estudo: Nome Cientifico Nome Comercial (Brasil) Cipionato de testosterona Deposteron Citrato de Clomifeno Clomid Decanoato de Nandrolona Deca-durabolin Decanoato, Isocaproato Fenilproprionato, e Durateston Propianato (Testosterona) Enantato de Testosterona Testosviron Metrandostenolona Dianabol Oxandrolona Anavar Stanozolol Winstrol Undecilenato de Baldenone Equifort Oximetolona Hemogenin Mentelona Primobolan Cloridrato de Clembuterol Clembuterol Mesterolona Proviron
Clomid can cause ovarian hyperstimulation syndrome, which in rare cases can be life-threatening.
The book "Game of Shadows," by two Chronicle reporters, says Estalella received a drug schedule from Greg Anderson, Bonds' trainer, advising him to use human growth hormone, the steroids "the cream" and "the clear," and the female fertility drug Clomid.