clobetasone

(redirected from Clobetasone butyrate)

clobetasone

A steroid drug used externally for skin and non-infective eye inflammation. A brand name is Cloburate and, in conjunction with an antibitic and an antifungal drug, Trimovate.

antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
Mentioned in ?
References in periodicals archive ?
She had a number of positives including cetearyl alcohol, sodium metabisulphite, and clobetasone butyrate. These are all components of Trimovate.
Whilst there has been a previous case report of concomitant sensitivity to sodium metabisulphite and clobetasone butyrate in a patient using Trimovate cream, (1) this is the first report of a patient reacting to three of the ingredients found in Trimovate--sodium metabisulphite, clobetasone butyrate, and cetearyl alcohol.
Clobetasone butyrate is often used in facial and flexural psoriasis.
Concomitant sensitivity to sodium metabisulfite and clobetasone butyrate in Trimovate cream.
In a study, Clobetasone butyrate caused more severe radiation reactions compared to hydrocortisone with similar prescribed radiation doses.
Effectiveness of topical steroids in the control of radiation dermatitis: a randomised trial using 1% hydrocortisone cream and 0.05% clobetasone butyrate (Eumovate).
The study found that in the United Kingdom, the prescribing ratio of emollients to topical steroids was almost 15 to 1, with the majority of steroid prescriptions being for a moderate potency drug (clobetasone butyrate, marketed as Eumovate).