Clear Cell Tumour

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A benign or malignant neoplasm composed of clear cells that may be of any embryologic (endo-, ecto-, meso-) or neuroectodermal origin; the cytoplasmic clearing may be real—lipid, mucopolysaccharide and mucosubstance—or artifactual, due to post-fixation shrinkage of cytoplasmic content away from an intact and more rigid cell membrane
Examples, clear cell tumours Balloon cell melanoma, signet ring cell carcinomas, renal cell, adrenal, ovary, parathyroid and thyroid carcinomas, clear cell tumours of tendons & aponeuroses, germ cell tumours—e.g., seminomas, dysgerminoma—histiocytosis X, lymphoma—B- and T- clear cell lymphomas—myeloma, clear cell type, myxoid lesions—benign and malignant—paraganglioma, and xanthoma. See Clear cell carcinoma
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The pathological differential diagnosis of MEC of the lacrimal gland may include inverted duct papillomas, cheilitis glandularis, necrotizing sialometaplasia, cystadenoma, cystadenocarcinoma, sebaceous carcinoma and other clear cell tumours, adenosquamous carcinoma, metastatic squamous cell carcinoma, and rarely pleomorphic adenoma.
Ovarian metastasis of CCRCC should be considered using a differential diagnosis of ovarian clear cell tumours, even if many years have passed after the diagnosis of a renal primary tumour, and even in cases without anamnestic data of RCC, since the metastasis could be discovered prior to the renal primary.
Our sub-analysis of the 544 clear cell tumours showed results similar to those of the larger cohort, with a tendency toward increased recurrence in patients who used metformin (HR, 1.7; 95% CI, 0.89-3.05[p = 0.09]), and no difference in CSS (HR, 0.9; 95% CI, 0.27-3.05 [p = 0.5]) (Fig.

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