Clear Cell Tumour

(redirected from Clear Cell Tumors)
A benign or malignant neoplasm composed of clear cells that may be of any embryologic (endo-, ecto-, meso-) or neuroectodermal origin; the cytoplasmic clearing may be real—lipid, mucopolysaccharide and mucosubstance—or artifactual, due to post-fixation shrinkage of cytoplasmic content away from an intact and more rigid cell membrane
Examples, clear cell tumours Balloon cell melanoma, signet ring cell carcinomas, renal cell, adrenal, ovary, parathyroid and thyroid carcinomas, clear cell tumours of tendons & aponeuroses, germ cell tumours—e.g., seminomas, dysgerminoma—histiocytosis X, lymphoma—B- and T- clear cell lymphomas—myeloma, clear cell type, myxoid lesions—benign and malignant—paraganglioma, and xanthoma. See Clear cell carcinoma
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Any of these tumors may have clear cell change, in some cases being so abundant as to mimic metastatic renal cell carcinoma or other clear cell tumors. The subtypes of acrospiroma are explored below.
Borderline clear cell tumors of the ovary account for less than 1% of borderline ovarian tumors [1].
Smoking was tied to a higher risk of mucinous tumors (RR per 20 pack-years, 1.20; 95% CI, 1.041.39) but was associated with a lower risk of clear cell tumors (RR, 0.68; 95% CI, 0.53-0.89).
Women who had given birth to one child had a 20 percent lower overall risk of ovarian cancer and a 40 percent lower risk of endometrioid and clear cell tumors (two specific types of ovarian cancer) than women with no children.
Rather than metaplasia of the surface epithelium, endometrioid and clear cell tumors may result from retrograde menstruation, with the fallopian tube acting as a conduit for cells to gain access to the peritoneal cavity and the ovarian surface.
Current studies implicate the VHL gene in the development of both familial and sporadic clear cell tumors.2 Up to 96% of clear cells RCC are associated with 3p deletion including somatic inactivating mutations of the VHL gene.
Histologically, clear cell odontogenic carcinoma (CCOC) consists of clear cells (Figure 2), which are positive for cytokeratin and negative for vimentin and also negative for mucicarmine, which differentiates it from some of the other clear cell tumors such as mucoepidermoid carcinoma and renal carcinoma and calcifying epithelial odontogenic tumor (CEOT) [54].
Hidradenomas can mimic cutaneous metastatic disease from clear cell tumors such as renal cell carcinoma.
For the study, the scientists evaluated mutations in 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients at Johns Hopkins and from institutions in Taiwan and Japan.
EMC must be distinguished from primary salivary gland neoplasms that contain clear cells (e.g., pleomorphic adenoma, myoepithelioma, oncocytoma, mucoepidermoid carcinoma, and clear cell carcinoma) and metastatic clear cell tumors (e.g., renal cell carcinoma and thyroid carcinoma).
CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol 2003;27:178-186.
Jones, a research associate at the Johns Hopkins Kimmel Cancer Center, Baltimore, and associates evaluated 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients (Science 2010 [doi:10.1126/science.1196333]).

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