Clear Cell Sarcoma

A sarcoma of young female adults, which affects the legs and acral regions. Clear cell sarcomas arise in tendons as circumscribed, but unencapsulated melanin-rich neuroectodermal tumours
Prognosis 45–60% death, late recurrence
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Lack of expression of melanocytic markers (eg MelanA, HMB45, MITF) is very helpful in the distinction of epithelioid MPNST from melanoma and clear cell sarcoma.
Liam Debbage, 31, was diagnosed with clear cell sarcoma 16 months ago after he injured his shoulder playing squash.
It is expressed in benign nerve sheath tumors, clear cell sarcoma, and melanoma (including desmoplastic and spindle cell variants).
Clear cell sarcoma (CCS) is a rare distinctive soft tissue sarcoma, known to originate from neural crest cells, that has been classified as a variant of melanoma since it was first reported in 1965 [1].
6) Clear cell sarcoma kidney & congenital mesoblastic nephroma (CMN) are rare in children.
Three-year-old Therese Faye Macababbad was diagnosed at Tawam Hospital, UAE's leading cancer hospital and a Johns Hopkins affiliate, with a clear cell sarcoma of the kidney on February 2010, when she was only 18 months old.
The team at Alder Hey found Ethan had clear cell sarcoma, and had only seen three tumours of this type in 25 years.
Diagnosed with clear cell sarcoma in 2007, the singer founded the Kate McGarrigle Fund cancer charity in 2008.
Doctors told Darren Grainger the only way to stop the clear cell sarcoma spreading through his body would be to amputate his right leg above the knee.
These tumors include alveolar soft part sarcoma (ASPS), clear cell sarcoma (CCS) and translocation-associated renal cell carcinoma (RCC).
This method is sensitive yet not specific for ES/PNET because there are other entities that demonstrate EWS gene rearrangement, including desmoplastic small round cell tumor, clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and myxoid liposarcoma.
The least common were Clear Cell Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Malignant Hemangiopericytoma, Alveolar Soft Part Sarcoma and Extraskeletal Osteosarcoma (One case each)

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