influenzae, to find a down regulation of genes called claudins
that encode proteins key to keeping the spaces between epithelial cells tight.
The patent is a composition of matter patent for compounds that modulate the family of adhesion molecules known as claudins
, which have a range of applications including enhancing the delivery of drugs to tumors and the inhibition of angiogenesis, a fundamental requirement for cancer growth.
7 and 8 (28,68,69) belong to a 20-member family of tight cell junction proteins, which have tissue-limited expression, including in the distal tubule and collecting duct cells of the kidney.
Molecular biologists at Nastech have cloned, expressed, and purified many of the important integral membrane proteins that make up tight junctions, including claudins
, occludin and junctional adhesion molecules.
Nastech researchers have discovered that specific proteins, referred to as claudins
3, 4, and 9, are selectively expressed in primary or normal respiratory epithelial cells that form tight junctions.
Its PDZ domains could bind to C-terminal sequences of claudins
and its GUK domains could bind to the C-terminal tail of occludin.
Usefulness of claudin
4 in the cytological diagnosis of serosal effusions.
Colin Stead landed one of 7lb 2oz, while Romanian angler Claudin
Marincas took a nice pollock of 5lb 8oz.
TJ proteins identified include transmembrane proteins; occludin and claudin
, and cytoplasmic plaque proteins; ZO-1, ZO-2, ZO-3, cingulin, and 7H6.
The main acknowledged influence on my understanding of international communism was, rather, Fernando Claudin
, whom Manley confusingly categorizes as a "traditionalist.
Anton can be relied on to produce the odd brilliant save while in front of him Dumitru Popescu and Vladimir Srirak combine well in the centre of defence.
Consider the words of Claudin
as he describes what a jaombilo is: